ArticlePloS one2014
Inverse association between serum bilirubin levels and arterial stiffness in Korean women with type 2 diabetes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies.Scientific reports · 2017Pooled it
- The Negative Relationship between Bilirubin Level and Diabetic Retinopathy: A Meta-Analysis.PloS one · 2016Pooled it
- High-normal serum bilirubin decreased the risk of lower limb atherosclerosis in type 2 diabetes: a real-world study.Diabetology & metabolic syndrome · 2023Article
- The Metabolic Characteristics of Patients at the Risk for Diabetic Foot Ulcer: A Comparative Study of Diabetic Patients with and without Diabetic Foot.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Low-normal serum unconjugated bilirubin levels are associated with late but not early carotid atherosclerotic lesions in T2DM subjects.Frontiers in endocrinology · 2022Article
- Prescription Opioid Use and Laboratory Value Derangements: A Cross-Sectional Analysis of NHANES Data.Pain physician · 2021Article
- Association Between Serum Bilirubin and the Progression of Carotid Atherosclerosis in Type 2 Diabetes.Journal of lipid and atherosclerosis · 2020Article
- Regenerative Effects of Heme Oxygenase Metabolites on Neuroinflammatory Diseases.International journal of molecular sciences · 2018Review
- Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications.Healthcare (Basel, Switzerland) · 2017Article
- Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus.Endocrine · 2017Article
- Interactive effect of serum uric acid and total bilirubin for cardiovascular disease in Chinese patients with type 2 diabetes.Scientific reports · 2016Article
- Association of Diabetic Nephropathy and Liver Disorders.Journal of clinical and diagnostic research : JCDR · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsiderable evidence suggests that bilirubin is a potent physiologic antioxidant that may provide important protection against cardiovascular disease (CVD) and inflammation. We investigated the relationship between serum total bilirubin (TB) levels and arterial stiffness, measured by the brachial-ankle pulse wave velocity (baPWV), in patients with type 2 diabetes.
methodsWe conducted a cross-sectional analysis of 1,711 subjects with type 2 diabetes (807 men and 904 women; mean age, 57.1 years). The subjects were stratified based on gender-specific tertiles of TB values, and a high baPWV was defined as greater than 1,745 cm/s ( >75th percentile).
resultsThe serum TB concentration was negatively correlated with the duration of diabetes, HbA1c, the 10-year Framingham risk score, and baPWV and was positively correlated with high-density lipoprotein cholesterol and the eGFR in both genders. Inverse association between TB categories and unadjusted prevalence of high PWV was only observed in women. After adjusting for confounding factors, the TB levels were inversely associated with a greater risk of a high baPWV, both as a continuous variable [a 1-SD difference; odds ratio (OR), 0.70; 95% confidence interval (CI), 0.54-0.90; P = 0.005] and when categorized in tertiles (the highest vs. the lowest tertile; OR, 0.49; 95% CI, 0.28-0.85; P = 0.011) in women but not in men. The relationship remained significant even after adjusting for retinopathy and nephropathy.
conclusionsLow TB levels were significantly associated with arterial stiffness in Korean women with type 2 diabetes. Our data suggested that bilirubin may protect against macrovascular disease in diabetic women.
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