ArticlePLoS genetics2014
Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- SCARECROW maintains the stem cell niche in Arabidopsis roots by ensuring telomere integrity.Plant physiology · 2023Article
- Quantification of 8-International journal of molecular sciences · 2022Article
- Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology.Communications biology · 2021Article
- Different DNA repair pathways are involved in single-strand break-induced genomic changes in plants.The Plant cell · 2021Article
- A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis.PLoS genetics · 2021Article
- A Mutation in DNA Polymerase α RescuesInternational journal of molecular sciences · 2021Article
- Roles of OB-Fold Proteins in Replication Stress.Frontiers in cell and developmental biology · 2020Review
- A high-quality sponge gourd (Horticulture research · 2020Article
- Plant DNA Polymerases.International journal of molecular sciences · 2019Review
- Review
- The Linker Histone GH1-HMGA1 Is Involved in Telomere Stability and DNA Damage Repair.Plant physiology · 2018Article
- Evolving Linear Chromosomes and Telomeres: A C-Strand-Centric View.Trends in biochemical sciences · 2018Review
- Emerging roles of CST in maintaining genome stability and human disease.Frontiers in bioscience (Landmark edition) · 2018Review
- Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes.Nucleic acids research · 2018Article
- STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.Nucleic acids research · 2017Article
- Protection of Arabidopsis Blunt-Ended Telomeres Is Mediated by a Physical Association with the Ku Heterodimer.The Plant cell · 2017Article
- Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres.Biochemistry · 2016Article
- STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.PLoS genetics · 2016Article
- Regulating telomere length from the inside out: the replication fork model.Genes & development · 2016Article
- Structure and function of the telomeric CST complex.Computational and structural biotechnology journal · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CST (Cdc13/CTC1-STN1-TEN1) complex was proposed to have evolved kingdom specific roles in telomere capping and replication. To shed light on its evolutionary conserved function, we examined the effect of STN1 dysfunction on telomere structure in plants. STN1 inactivation in Arabidopsis leads to a progressive loss of telomeric DNA and the onset of telomeric defects depends on the initial telomere size. While EXO1 aggravates defects associated with STN1 dysfunction, it does not contribute to the formation of long G-overhangs. Instead, these G-overhangs arise, at least partially, from telomerase-mediated telomere extension indicating a deficiency in C-strand fill-in synthesis. Analysis of hypomorphic DNA polymerase α mutants revealed that the impaired function of a general replication factor mimics the telomeric defects associated with CST dysfunction. Furthermore, we show that STN1-deficiency hinders re-replication of heterochromatic regions to a similar extent as polymerase α mutations. This comparative analysis of stn1 and pol α mutants suggests that STN1 plays a genome-wide role in DNA replication and that chromosome-end deprotection in stn1 mutants may represent a manifestation of aberrant replication through telomeres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.