ArticlePLoS computational biology2014
Linear motif-mediated interactions have contributed to the evolution of modularity in complex protein interaction networks.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Review
- IMCC: A Novel Quantitative Approach Revealing Variation of Global Modular Map and Local Inter-Module Coordination Among Differential Drug's Targeted Cerebral Ischemic Networks.Frontiers in pharmacology · 2021Article
- Article
- Link clustering explains non-central and contextually essential genes in protein interaction networks.Scientific reports · 2019Article
- Systematic prediction of FFAT motifs across eukaryote proteomes identifies nucleolar and eisosome proteins with the predicted capacity to form bridges to the endoplasmic reticulum.Contact (Thousand Oaks (Ventura County, Calif.)) · 2019Article
- Controllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family.Scientific reports · 2016Article
- Hammock: a hidden Markov model-based peptide clustering algorithm to identify protein-interaction consensus motifs in large datasets.Bioinformatics (Oxford, England) · 2016Article
- K-shell Analysis Reveals Distinct Functional Parts in an Electron Transfer Network and Its Implications for Extracellular Electron Transfer.Frontiers in microbiology · 2016Article
- How do disordered regions achieve comparable functions to structured domains?Protein science : a publication of the Protein Society · 2015Review
- LMPID: a manually curated database of linear motifs mediating protein-protein interactions.Database : the journal of biological databases and curation · 2015Article
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4 authors.
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Abstract
The modular architecture of protein-protein interaction (PPI) networks is evident in diverse species with a wide range of complexity. However, the molecular components that lead to the evolution of modularity in PPI networks have not been clearly identified. Here, we show that weak domain-linear motif interactions (DLIs) are more likely to connect different biological modules than strong domain-domain interactions (DDIs). This molecular division of labor is essential for the evolution of modularity in the complex PPI networks of diverse eukaryotic species. In particular, DLIs may compensate for the reduction in module boundaries that originate from increased connections between different modules in complex PPI networks. In addition, we show that the identification of biological modules can be greatly improved by including molecular characteristics of protein interactions. Our findings suggest that transient interactions have played a unique role in shaping the architecture and modularity of biological networks over the course of evolution.
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