ArticleGut pathogens2014
Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study.
Article in Gut pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Biomarker Characterization and Prediction of Virulence and Antibiotic Resistance fromBiomolecules · 2022Review
- Overview ofGut and liver · 2021Review
- Helicobacter pylori in the Indonesian Malay's descendants might be imported from other ethnicities.Gut pathogens · 2021Article
- Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia.Gut and liver · 2020Review
- Structure of cytotoxic associated antigen A protein ofVeterinary world · 2020Article
- Review of current diagnostic methods and advances inWorld journal of gastroenterology · 2019Review
- Analysis of risks of gastric cancer by gastric mucosa among Indonesian ethnic groups.PloS one · 2019Article
- Helicobacter pylori in patients with gastritis in West Cameroon: prevalence and risk factors for infection.BMC research notes · 2018Article
- Prevalence of CagA and antimicrobial sensitivity ofInfectious agents and cancer · 2018Article
- Gastric mucosal status in populations with a low prevalence of Helicobacter pylori in Indonesia.PloS one · 2017Article
- Prevalence and Risk Factors for Helicobacter Pylori Infection among Healthy Inhabitants in Northern Jakarta, IndonesiaAsian Pacific journal of cancer prevention : APJCP · 2016Article
- Diagnostic Methods of Helicobacter pylori Infection for Epidemiological Studies: Critical Importance of Indirect Test Validation.BioMed research international · 2016Review
- Helicobacter pylori virulence genes in the five largest islands of Indonesia.Gut pathogens · 2015Article
- Validation of Urine Test for Detection of Helicobacter pylori Infection in Indonesian Population.BioMed research international · 2015Article
- Risk Factors and Prevalence of Helicobacter pylori in Five Largest Islands of Indonesia: A Preliminary Study.PloS one · 2015Article
- Allergies, Helicobacter pylori and the continental enigmas.Frontiers in microbiology · 2015Review
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundSulawesi in Indonesia has a unique geographical profile with assumed separation from Sundaland. Studies of Helicobacter pylori in this region are rare due to the region's rural location and lack of endoscopy equipment. Indirect methods are, therefore, the most appropriate for measuring H. pylori infection in these areas; with the disposable gastric brush test, we can obtain gastric juice as well as small gastric tissue samples for H. pylori culture. We investigated the prevalence of H. pylori infection and evaluated human migration patterns in the remote areas of North Sulawesi.
methodsWe recruited a total of 251 consecutive adult volunteers and 131 elementary school children. H. pylori infection was determined by urine antibody test. A gastric brush test was used to culture H. pylori. We used next-generation and polymerase chain reaction based sequencing to determine virulence factors and multi-locus sequence typing (MLST).
resultsThe overall H. pylori prevalence was only 14.3% for adults and 3.8% for children, and 13.6% and 16.7% in Minahasanese and Mongondownese participants, respectively. We isolated a single H. pylori strain, termed -Manado-1. Manado-1 was East Asian type cagA (ABD type), vacA s1c-m1b, iceA1 positive/iceA2 negative, jhp0562-positive/β-(1,3) galT-negative, oipA "on", and dupA-negative. Phylogenetic analyses showed the strain to be hspMaori type, a major type observed in native Taiwanese and Maori tribes.
conclusionsOur data support that very low H. pylori infection prevalence in Indonesia. Identification of hspMaori type H. pylori in North Sulawesi may support the hypothesis that North Sulawesi people migrated from north.
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