ArticlePloS one2014
Study on the promotion of bacterial biofilm formation by a Salmonella conjugative plasmid and the underlying mechanism.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of bcsE, luxS and rfaG genes on the physiology and pathogenicity of Salmonella Typhimurium.Archives of microbiology · 2025Article
- Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based onInternational journal of molecular sciences · 2024Review
- Regulatory Mechanisms and Physiological Impacts of Quorum Sensing in Gram-Negative Bacteria.Infection and drug resistance · 2024Review
- Furanone and phytol influence metabolic phenotypes regulated by acyl-homoserine lactone in Salmonella.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Regulatory Mechanisms between Quorum Sensing and Virulence inMicroorganisms · 2022Review
- The Complex Mechanism of the Salmonella typhi Biofilm Formation That Facilitates Pathogenicity: A ReviewInternational journal of molecular sciences · 2022Review
- Synergistic antimicrobial and antibiofilm activities of piperic acid and 4-ethylpiperic acid amides in combination with ciprofloxacin.The Journal of antibiotics · 2022Article
- Alteration ofMicroorganisms · 2021Article
- Quantitative proteomics implicates YggT in streptomycin resistance in Salmonella enterica serovar Enteritidis.Biotechnology letters · 2021Article
- Plasmid Transfer by Conjugation in Gram-Negative Bacteria: From the Cellular to the Community Level.Genes · 2020Review
- Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival.Frontiers in microbiology · 2018Review
- N-dodecanoyl-homoserine lactone influences the levels of thiol and proteins related to oxidation-reduction process in Salmonella.PloS one · 2018Article
- Human Gut Microbiota: Toward an Ecology of Disease.Frontiers in microbiology · 2017Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the effect of the pRST98 plasmid, originally isolated from Salmonella enterica serovar Typhi (S. Typhi), on biofilm (BF) formation, we carried out in vitro experiments using S. Typhi, Salmonella enterica serovar Typhimurium (S. Typhimurium) and Escherichia coli (E. coli). We further explored the effects of pRST98 in vivo by establishing two animal models, a tumor-bearing mouse model and a mouse urethral catheter model. Moreover, we examined the relationship between the quorum-sensing (QS) system and pRST98-mediated BF formation. These studies showed that pRST98 enhanced BF formation in different bacteria in vitro. In both animal models, pRST98 promoted BF formation and caused more severe pathological changes. It was previously reported that Salmonella senses exogenous N-acylhomoserine lactones (AHLs) through the regulatory protein SdiA and regulates the expression of genes including the virulence gene rck, which is located on the virulence plasmid of some serotypes of Salmonella. In this study, we confirmed the locus of the rck gene on pRST98 and found that AHLs increased rck expression in pRST98-carrying strains, thereby enhancing bacterial adherence, serum resistance and bacterial BF formation. In conclusion, the Salmonella conjugative plasmid pRST98 promotes bacterial BF formation both in vitro and in vivo, and the mechanism may relate to the AHL-SdiA-Rck signaling pathway.
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