SynthesisPloS one2014
Confluent granulomas and ulcers lined by epithelioid histiocytes: new ideal method for differentiation of ITB and CD? A meta analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Histological approach and differentiation of Crohn's disease and gastrointestinal tuberculosis: Recommendations from the joint IAPM-ISG-CCFI Working Group.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Guideline
- Meta-Analytic Bayesian Model For Differentiating Intestinal Tuberculosis from Crohn's Disease.The American journal of gastroenterology · 2017Pooled it
- TB or Not TB? A Case of Necrotizing Granulomatous Ileitis.Digestive diseases and sciences · 2026Article
- The Overlap Between Crohn's Disease and Intestinal Tuberculosis: A Never-Ending Story.Medicina (Kaunas, Lithuania) · 2026Review
- Diagnosis of Pediatric Inflammatory Bowel Disease (PIBD)-Implications for the Asia-Pacific Region: A Position Paper from the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition PIBD Working Group.Pediatric gastroenterology, hepatology & nutrition · 2026Review
- Outcomes of Abdominal Tuberculosis Referred for Surgical Management in a Tertiary Care Center in Nepal.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Immunohistochemistry and real-time Polymerase Chain Reaction: importance in the diagnosis of intestinal tuberculosis in a Peruvian population.BMC gastroenterology · 2024Observational
- Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review.BMC gastroenterology · 2023Review
- Etiological spectrum of isolated ileo-cecal ulcers in patients with gastrointestinal symptoms.Journal of clinical and translational research · 2023Article
- Evidence-based approach to diagnosis and management of abdominal tuberculosis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Review
- Saudi Arabia consensus guidance for the diagnosis and management of adults with inflammatory bowel disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2022Article
- Addition of computed tomography chest increases the diagnosis rate in patients with suspected intestinal tuberculosis.Intestinal research · 2022Article
- A combination of circulating microRNA-375-3p and chemokines CCL11, CXCL12, and G-CSF differentiate Crohn's disease and intestinal tuberculosis.Scientific reports · 2021Article
- Intestinal tuberculosis or Crohn's disease: Illusion or delusion or allusion.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- TB or Not TB: Crohn's Disease, Peritoneal Tuberculosis, or Both?Digestive diseases and sciences · 2019Article
- Differentiating Crohn's disease from intestinal tuberculosis.World journal of gastroenterology · 2019Review
- Clinical and laboratory features of intestinal tuberculosis.Clinical and experimental gastroenterology · 2018Article
- Accuracy of computed tomographic features in differentiating intestinal tuberculosis from Crohn's disease: a systematic review with meta-analysis.Intestinal research · 2017Review
- Proteome analysis of the macroscopically affected colonic mucosa of Crohn's disease and intestinal tuberculosis.Scientific reports · 2016Article
- Extranodal NK/T-cell lymphoma, nasal type: a case report of 7-year natural course and review of literature.International journal of clinical and experimental pathology · 2015Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are few widely accepted criteria other than caseation, which has low sensitivity, for differentiating intestinal tuberculosis (ITB) and Crohn's disease (CD).
objectiveWe performed a meta-analysis to evaluate the use of confluent granulomas and ulcers lined by epithelioid histiocytes as histological methods for differentiating ITB and CD, compared with that of caseation.
methodsWe searched PubMed, Medline, Embase, Web of Science, the Cochrane Library and Chinese Biomedicine Database for all relevant studies on the histological differentiation of ITB and CD. Sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated for each study. Study quality and heterogeneity were assessed. Meta-regression analysis and sensitivity analyses were performed.
resultsTen randomized trials involving 316 ITB and 376 CD patients were included. The results showed that analysis of caseation showed an overall weighted area under the curve (AUC) of 0.9966, overall sensitivity and specificity were 0.21 and 1.00, respectively, with a positive likelihood ratio (+LR) of 10.79, negative likelihood ratio(-LR) of 0.82 and DOR of 13.74. Confluent granulomas had a lower overall weighted AUC of 0.9381, sensitivity and specificity were 0.38 and 0.99, respectively, with a +LR of 16.29, -LR of 0.65 and DOR of 26.52. Overall weighted AUC for ulcers lined by epithelioid histiocytes was 0.9017, sensitivity and specificity were 0.41 and 0.94, respectively, with a +LR of 6.46, -LR of 0.54 and DOR of 13.17. Significant heterogeneity was noted for the studies. Meta-regression analysis showed that study source, publication year, size, design and quality did not affect heterogeneity.
conclusionConfluent granulomas and ulcers lined by epithelioid histiocytes are helpful in distinguishing ITB from CD, which may provide a new method, other than caseating granulomas and acid-fast bacilli, to differentiate ITB and CD in mucosal biopsies.
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