Evidence map›Paper›PMID 25298775›Full record

ArticleDementia and geriatric cognitive disorders extra2014

The Memory Alteration Test Discriminates between Cognitively Healthy Status, Mild Cognitive Impairment and Alzheimer's Disease.

Nilton Custodio, David Lira, Eder Herrera-Perez, Liza Nuñez Del Prado, José Parodi, Erik Guevara-Silva, Sheila Castro-Suarez, Rosa Montesinos, Patricia Cortijo

Abstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders extra, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Validation of the RUDAS in Patients With a Middle-Level Education in Lima, Peru.American journal of Alzheimer's disease and other dementias
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nilton CustodioServicio de Neurología, Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru.
David LiraServicio de Neurología, Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru.
Eder Herrera-PerezUnidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Diseño y Elaboración de Proyectos de Investigación, Universidad Peruana Cayetano Heredia, Lima, Peru ; Centro de Investigación para el Desarrollo Integral y Sostenible, Universidad Peruana Cayetano Heredia, Lima, Peru.
Liza Nuñez Del PradoUnidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru ; Servicio de Neurología, Clínica Maisson de Sante, Universidad San Martín de Porres, Lima, Peru.
José ParodiCentro de Investigación del Envejecimiento, Facultad de Medicina Humana, Universidad San Martín de Porres, Lima, Peru.
Erik Guevara-SilvaDepartamento de Medicina, Hospital de Chancay, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Sheila Castro-SuarezUnidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru ; Servicio de Neurología de la Conducta, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Rosa MontesinosUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Universidad Peruana Cayetano Heredia, Lima, Peru ; Servicio de Medicina Física y Rehabilitación, Clínica Internacional, Universidad Peruana Cayetano Heredia, Lima, Peru ; Unidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru.
Patricia CortijoUnidad de Investigación, Instituto Peruano de Neurociencias, Universidad Peruana Cayetano Heredia, Lima, Peru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsDementia is a worldwide public health problem and there are several diagnostic tools for its assessment. The aim of this study was to evaluate the performance of the Memory Alteration Test (M@T) to discriminate between patients with early Alzheimer's disease (AD), patients with amnestic mild cognitive impairment (a-MCI), and subjects with a cognitively healthy status (CHS).

methodsThe discriminative validity was assessed in a sample of 90 patients with AD, 45 patients with a-MCI, and 180 subjects with CHS. Clinical, functional, and cognitive studies were independently performed in a blinded fashion and the gold standard diagnosis was established by consensus on the basis of these results. The test performance was assessed by means of a receiver operating characteristic curve analysis as area under the curve (AUC).

resultsM@T mean scores were 17.7 (SD = 5.7) in AD, 30.8 (SD = 2.3) in a-MCI, and 44.5 (SD = 3.1) in CHS. A cutoff score of 37 points had a sensitivity of 98.3% and a specificity of 97.8% to differentiate a-MCI from CHS (AUC = 0.999). A cutoff score of 27 points had a sensitivity of 100% and a specificity of 98.9% to differentiate mild AD from a-MCI and from CHS (AUC = 1.000).

conclusionsThe M@T had a high performance in the discrimination between early AD, a-MCI and CHS.

Indexed as

DementiaDifferential diagnosisMemory alteration test

Identifiers

PMID25298775
PMCPMC4176469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.