ArticleIndian journal of pharmacology
Chemopreventive potential of Apium leptophyllum (Pers.) against DMBA induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers in Swiss mice.
Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- From Network Analysis to Functional Nutraceutical Protection: Pistacia lentiscus L. Mitigates DMBA-Induced Liver Damage Through AhR/ARNT Pathway Regulation.Chemistry & biodiversity · 2026Article
- Antidiarrhoeal investigation of Apium leptophyllum (Pers.) by modulation of NaBiomedical journal · 2016Article
- Is chemo-preventive effect of Apium leptophyllum (Pers.) caused only by anti-oxidative property of flavonoids?Indian journal of pharmacologyArticle
- Author's Reply.Indian journal of pharmacologyArticle
- Pharmacological evaluation ofJournal of pharmacy & bioallied sciencesArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe study was designed to investigate the chemopreventive potential of flavonoidal fractions of Apium leptophyllum fruits (FFALF) on Swiss mice. MATERIALS AND
methodsSkin tumor or papilloma was developed by topical application of DMBA (25 μg in 0.1 ml acetone) on intrascapular region of mice, twice weekly for 8 weeks. The animals were divided into six groups: Group I (vehicle control); group II (FFALF control, 5 mg/kg); group III (carcinogenic control, DMBA treated initially for 8 weeks); and group IV, V and VI as pre-treated group (FFALF 5, 10 and 20 mg/kg respectively for 16 weeks along with DMBA treatment). After the 16(th) week of treatment; the tumor morphology, skin histopathology, and biochemical and antioxidant biomarkers were measured and compared with carcinogenic control as well as vehicle control.
resultsThe co-administration of FFALF with DMBA-treated groups showed significant (P ≤ 0.001) prevention against skin papilloma and normalized the status of lipid peroxidation with antioxidant biomarkers in a dose-dependent manner as compared to carcinogenic control.
conclusionsThus, the present study suggests that the FFALF is non-carcinogenic and has chemopreventive potential on DMBA-induced carcinogenesis in mouse, which may be due to the modulation of cutaneous lipid peroxidation or enhancement of total antioxidant capacity.
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