ArticleInternational journal of epidemiology2014
Elevated levels of protein in urine in adulthood after exposure to the Chinese famine of 1959-61 during gestation and the early postnatal period.
Article in International journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Association between early exposure to famine and risk of renal impairment in adulthood: a systematic review and meta-analysis.Nutrition & diabetes · 2024Pooled it
- The Relationship between Maternal Nutrition during Pregnancy and Offspring Kidney Structure and Function in Humans: A Systematic Review.Nutrients · 2018Pooled it
- Longitudinal association between early-life famine exposure and risk of microvascular complications of type 2 diabetes in adulthood: A retrospective cohort in Tianjin, China.Asia Pacific journal of clinical nutrition · 2026Article
- Elevated risk of infectious diseases in adulthood after prenatal or early postnatal exposure to the Great Chinese Famine.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Link between Prenatal Stage of Life during the Great Chinese Famine and Subsequent Depressive Symptoms among Middle-Aged and Older Adults.Nutrients · 2023Article
- What a paediatric nephrologist should know about preeclampsia and why it matters.Pediatric nephrology (Berlin, Germany) · 2022Review
- Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney.Frontiers in pediatrics · 2022Review
- Consequences of exposure to prenatal famine on estimated glomerular filtration rate and risk of chronic kidney disease among survivors of the great Ethiopian famine (1983-85): a historical cohort study.Nutrition journal · 2021Article
- Impact of early-life diet on long-term renal health.Molecular and cellular pediatrics · 2020Review
- Article
- Review
- In utero exposure to the Great Chinese Famine and risk of intracerebral hemorrhage in midlife.Neurology · 2020Article
- Prenatal war exposure and schizophrenia in adulthood: evidence from the Sino-Japanese War of 1937-1945.Social psychiatry and psychiatric epidemiology · 2019Article
- The effect of Chinese famine exposure in early life on dietary patterns and chronic diseases of adults.Public health nutrition · 2019Article
- Early-life exposure to severe famine and subsequent risk of depressive symptoms in late adulthood: the China Health and Retirement Longitudinal Study.The British journal of psychiatry : the journal of mental science · 2018Article
- PALTEM: What Parameters Should Be Collected in Disaster Settings to Assess the Long-Term Outcomes of Famine?International journal of environmental research and public health · 2018Review
- Self-reported sleep duration and daytime napping are associated with renal hyperfiltration in general population.Sleep & breathing = Schlaf & Atmung · 2018Article
- Exposure to famine in early life and chronic kidney diseases in adulthood.Nutrition & diabetes · 2018Article
- Developmental Programming of Renal Function and Re-Programming Approaches.Frontiers in pediatrics · 2018Review
- Increase in the prevalence of hypertension among adults exposed to the Great Chinese Famine during early life.Environmental health and preventive medicine · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnimal models have suggested that undernutrition during gestation and the early postnatal period may adversely affect kidney development and compromise renal function. As a natural experiment, famines provide an opportunity to test such potential effects in humans. We assessed whether exposure to the Chinese famine of 1959-1961 during gestation and early postnatal life was associated with the levels of proteinuria among female adults three decades after exposure to the famine.
methodsWe measured famine intensity using the cohort size shrinkage index and we constructed a difference-in-difference model to compare the levels of proteinuria, measured with a dipstick test of random urine specimens, among Chinese women (n = 70 543) whose exposure status to the famine varied across birth cohorts (born before, during or after the famine) and counties of residence with different degrees of famine intensity.
resultsFamine exposure was associated with a greater risk [odds ratio (OR) = 1.54; 95% confidence interval (CI): 1.04, 2.28; P = 0.029) of having higher level of proteinuria among women born during the famine years (1959-61) compared with the unexposed post famine-born cohort (1964-65) in rural samples. No association was observed among urban samples. Results were robust to adjustment for covariates.
conclusionsSevere undernutrition during gestation and the early postnatal period may have long-term effects on levels of proteinuria in humans, but the effect sizes may be small.
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