Trial reportThe Journal of infectious diseases2015
Cytotoxic Virulence Predicts Mortality in Nosocomial Pneumonia Due to Methicillin-Resistant Staphylococcus aureus.
Trial report in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Metabolic reprogramming promotesMicrobiology (Reading, England) · 2026Article
- Molecular mechanism of crisaborole combined with erythromycin against methicillin-resistantFrontiers in microbiology · 2025Article
- Article
- Dietary and water restriction leads to increased susceptibility to antimicrobial resistant pathogens.Science advances · 2024Article
- Microbiota and metabolic adaptation shapebioRxiv : the preprint server for biology · 2024Article
- A Study on the Epidemiological-Molecular Role ofAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Article
- Extensive re-modelling of the cell wall during the development ofbioRxiv : the preprint server for biology · 2023Article
- Effectiveness and Safety of Linezolid Versus Vancomycin, Teicoplanin, or Daptomycin against Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Review
- MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation.Cell host & microbe · 2023Article
- The tempo and mode of gene regulatory programs during bacterial infection.Cell reports · 2022Article
- Diagnostic MALDI-TOF MS can differentiate between high and low toxicMicrobiology (Reading, England) · 2022Article
- Microbiome-Independent Effects of Antibiotics in a Murine Model of Nosocomial Infections.mBio · 2022Article
- Observational
- Look Who's Talking: Host and Pathogen Drivers ofInternational journal of molecular sciences · 2022Review
- Antimicrobial resistance determinants are associated withMicrobial genomics · 2021Article
- Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation.Nature communications · 2021Article
- Genotypic and Phenotypic Characterization ofToxins · 2021Observational
- Investigation of Virulence Genes ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The current study identified bacterial factors that may improve management of methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Isolates were obtained from 386 patients enrolled in a randomized, controlled study of antibiotic efficacy. Isolates were screened for production of virulence factors and for vancomycin susceptibility. After adjustment for host factors such as severity of illness and treatment modality, cytotoxic activity was strongly and inversely associated with mortality; however, it had no effect on clinical cure. Isolates having low cytotoxicity, which were derived largely from healthcare-associated clones, exhibited a greater prevalence of vancomycin heteroresistance, and they were recovered more often from patients who were older and frailer. Additionally, a clone with low cytotoxic activity was associated with death and poor clinical improvement. Clone specificity and attenuated virulence appear to be associated with outcome. To our knowledge, these are the first correlations between MRSA virulence and mortality in nosocomial pneumonia.
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