ArticleScientific reports2014
A high-resolution LC-MS-based secondary metabolite fingerprint database of marine bacteria.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- High-Seas Marine Microorganism Delivers an Extract That Dampens LPS-Driven Pro-Inflammatory Signaling:Marine drugs · 2025Article
- Antifungal potential of marine bacterial compounds in inhibitingFrontiers in pharmacology · 2024Article
- Revealing Genome-Based Biosynthetic Potential ofAntibiotics (Basel, Switzerland) · 2022Article
- Integrated Genomic and Functional Characterization of the Anti-diabetic Potential of Arthrobacter sp. SW1.Current microbiology · 2021Article
- Analysis of Antimicrobial Peptide Metabolome of Bacterial Endophyte Isolated From Traditionally Used Medicinal PlantFrontiers in microbiology · 2021Article
- Genomic and functional features of the biosurfactant producing Bacillus sp. AM13.Functional & integrative genomics · 2016Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine bacteria are the most widely distributed organisms in the ocean environment and produce a wide variety of secondary metabolites. However, traditional screening for bioactive natural compounds is greatly hindered by the lack of a systematic way of cataloguing the chemical profiles of bacterial strains found in nature. Here we present a chemical fingerprint database of marine bacteria based on their secondary metabolite profiles, acquired by high-resolution LC-MS. Till now, 1,430 bacterial strains spanning 168 known species collected from different marine environments were cultured and profiled. Using this database, we demonstrated that secondary metabolite profile similarity is approximately, but not always, correlated with taxonomical similarity. We also validated the ability of this database to find species-specific metabolites, as well as to discover known bioactive compounds from previously unknown sources. An online interface to this database, as well as the accompanying software, is provided freely for the community to use.
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