ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Early monocular defocus disrupts the normal development of receptive-field structure in V2 neurons of macaque monkeys.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Amblyopia: progress and promise of functional magnetic resonance imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Pooled it
- Binocular treatment of amblyopia using videogames (BRAVO): study protocol for a randomised controlled trial.Trials · 2016Trial
- Identification of letters distorted by physiologically-inspired spatial scrambling.PLoS computational biology · 2026Article
- Neurophysiological basis for visual distortions in amblyopia.Frontiers in neuroscience · 2026Review
- Differential Effects of Balanced and Imbalanced Binocular Stimulation on Visual Cortex Responses in Amblyopic Children.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Slow binocular reading during rapid serial visual presentation (RSVP) in children with amblyopia and the role of fixation instability.Vision research · 2025Article
- Eye-hand coordination during visually-guided reaching in children with monocular deprivation amblyopia.Vision research · 2025Article
- Phantom Forms in Amblyopic Vision and what they reveal about the Generative Brain.bioRxiv : the preprint server for biology · 2025Article
- Visual Distortions in Human Amblyopia Are Correlated with Deficits in Contrast Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Comparative Neuroplasticity in Frontal- and Lateral-Eyed Mammals With Induced-Binocular Vision Dysfunction: Insights From Monocular Deprivation Models.The European journal of neuroscience · 2025Review
- Structural and functional alterations in the brains of patients with anisometropic and strabismic amblyopia: a systematic review of magnetic resonance imaging studies.Neural regeneration research · 2023Article
- Amblyopia and the whole child.Progress in retinal and eye research · 2023Review
- Contour integration deficits at high spatial frequencies in children treated for anisometropic amblyopia.Frontiers in neuroscience · 2023Article
- Recent Advances in Screening and Treatment for Amblyopia.Ophthalmology and therapy · 2021Review
- Rethinking amblyopia 2020.Vision research · 2020Review
- Attention in visually typical and amblyopic children.Journal of vision · 2020Article
- Altered functional interactions between neurons in primary visual cortex of macaque monkeys with experimental amblyopia.Journal of neurophysiology · 2019Article
- The Importance of the Interaction Between Ocular Motor Function and Vision During Human Infancy.Annual review of vision science · 2019Review
- Impaired Fellow Eye Motion Perception and Abnormal Binocular Function.Investigative ophthalmology & visual science · 2019Article
- Spiking Noise and Information Density of Neurons in Visual Area V2 of Infant Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Experiencing different quality images in the two eyes soon after birth can cause amblyopia, a developmental vision disorder. Amblyopic humans show the reduced capacity for judging the relative position of a visual target in reference to nearby stimulus elements (position uncertainty) and often experience visual image distortion. Although abnormal pooling of local stimulus information by neurons beyond striate cortex (V1) is often suggested as a neural basis of these deficits, extrastriate neurons in the amblyopic brain have rarely been studied using microelectrode recording methods. The receptive field (RF) of neurons in visual area V2 in normal monkeys is made up of multiple subfields that are thought to reflect V1 inputs and are capable of encoding the spatial relationship between local stimulus features. We created primate models of anisometropic amblyopia and analyzed the RF subfield maps for multiple nearby V2 neurons of anesthetized monkeys by using dynamic two-dimensional noise stimuli and reverse correlation methods. Unlike in normal monkeys, the subfield maps of V2 neurons in amblyopic monkeys were severely disorganized: subfield maps showed higher heterogeneity within each neuron as well as across nearby neurons. Amblyopic V2 neurons exhibited robust binocular suppression and the strength of the suppression was positively correlated with the degree of hereogeneity and the severity of amblyopia in individual monkeys. Our results suggest that the disorganized subfield maps and robust binocular suppression of amblyopic V2 neurons are likely to adversely affect the higher stages of cortical processing resulting in position uncertainty and image distortion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.