ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Simultaneous encoding of sensory features: the role of multiplexing and noise in tactile perception and neural representation.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Self-supervised learning of scale-invariant neural representations of space and time.Journal of computational neuroscience · 2025Article
- Progress of the Impact of Terahertz Radiation on Ion Channel Kinetics in Neuronal Cells.Neuroscience bulletin · 2024Review
- A 3D atlas of functional human brain energetic connectome based on neuropil distribution.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism.Frontiers in cellular neuroscience · 2023Article
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- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Energy efficiency and coding of neural network.Frontiers in neuroscience · 2022Article
- Changes in Brain Functional Network Connectivity in Adult Moyamoya Diseases.Cognitive neurodynamics · 2021Article
- Short term depression, presynaptic inhibition and local neuron diversity play key functional roles in the insect antennal lobe.Journal of computational neuroscience · 2020Article
- Functional Specialization of Interneuron Dendrites: Identification of Action Potential Initiation Zone in Axonless Olfactory Bulb Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sparse Representation in Awake Auditory Cortex: Cell-type Dependence, Synaptic Mechanisms, Developmental Emergence, and Modulation.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Article
- Efficient Coding and Energy Efficiency Are Promoted by Balanced Excitatory and Inhibitory Synaptic Currents in Neuronal Network.Frontiers in cellular neuroscience · 2018Article
- Synaptic E-I Balance Underlies Efficient Neural Coding.Frontiers in neuroscience · 2018Review
- The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases.Neurobiology of disease · 2018Article
- Dense encoding of natural odorants by ensembles of sparsely activated neurons in the olfactory bulb.Scientific reports · 2016Article
- Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb.Frontiers in computational neuroscience · 2016Article
- Odor Experience Facilitates Sparse Representations of New Odors in a Large-Scale Olfactory Bulb Model.Frontiers in neuroanatomy · 2016Article
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
The precise mechanism by which synaptic excitation and inhibition interact with each other in odor coding through the unique dendrodendritic synaptic microcircuits present in olfactory bulb is unknown. Here a scaled-up model of the mitral-granule cell network in the rodent olfactory bulb is used to analyze dendrodendritic processing of experimentally determined odor patterns. We found that the interaction between excitation and inhibition is responsible for two fundamental computational mechanisms: (1) a balanced excitation/inhibition in strongly activated mitral cells, leading to a sparse representation of odorant input, and (2) an unbalanced excitation/inhibition (inhibition dominated) in surrounding weakly activated mitral cells, leading to lateral inhibition. These results suggest how both mechanisms can carry information about the input patterns, with optimal level of synaptic excitation and inhibition producing the highest level of sparseness and decorrelation in the network response. The results suggest how the learning process, through the emergent development of these mechanisms, can enhance odor representation of olfactory bulb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.