ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
A feedforward inhibitory circuit mediates lateral refinement of sensory representation in upper layer 2/3 of mouse primary auditory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed.
- Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Article
- Article
- Patchy harmonic functional connectivity of the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Parvalbumin neurons and cortical coding of dynamic stimuli: a network model.Journal of neurophysiology · 2025Article
- Article
- Dynamical mechanisms of how an RNN keeps a beat, uncovered with a low-dimensional reduced model.Scientific reports · 2024Article
- Functional diversities within neurons and astrocytes in the adult rat auditory cortex revealed by single-nucleus RNA sequencing.Scientific reports · 2024Article
- Cell-type-specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance.Nature communications · 2024Article
- Developmental hearing loss-induced perceptual deficits are rescued by genetic restoration of cortical inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cortical determinants of loudness perception and auditory hypersensitivity.bioRxiv : the preprint server for biology · 2024Article
- Effective Regulation of Auditory Processing by Parvalbumin Interneurons in the Tail of the Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neurocomputational modeling of speech motor development.Journal of child language · 2023Review
- Parvalbumin neurons enhance temporal coding and reduce cortical noise in complex auditory scenes.Communications biology · 2023Article
- Article
- Pairing with Enriched Sound Exposure Restores Auditory Processing Degraded by an Antidepressant.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The local and long-range input landscape of inhibitory neurons in mouse auditory cortex.The Journal of comparative neurology · 2023Article
- Age-related changes in excitatory and inhibitory intra-cortical circuits in auditory cortex of C57Bl/6 mice.Hearing research · 2023Article
- Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAbioRxiv : the preprint server for biology · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Sensory information undergoes ordered and coordinated processing across cortical layers. Whereas cortical layer (L) 4 faithfully acquires thalamic information, the superficial layers appear well staged for more refined processing of L4-relayed signals to generate corticocortical outputs. However, the specific role of superficial layer processing and how it is specified by local synaptic circuits remains not well understood. Here, in the mouse primary auditory cortex, we showed that upper L2/3 circuits play a crucial role in refining functional selectivity of excitatory neurons by sharpening auditory tonal receptive fields and enhancing contrast of frequency representation. This refinement is mediated by synaptic inhibition being more broadly recruited than excitation, with the inhibition predominantly originating from interneurons in the same cortical layer. By comparing the onsets of synaptic inputs as well as of spiking responses of different types of neuron, we found that the broadly tuned, fast responding inhibition observed in excitatory cells can be primarily attributed to feedforward inhibition originating from parvalbumin (PV)-positive neurons, whereas somatostatin (SOM)-positive interneurons respond much later compared with the onset of inhibitory inputs to excitatory neurons. We propose that the feedforward circuit-mediated inhibition from PV neurons, which has an analogous function to lateral inhibition, enables upper L2/3 excitatory neurons to rapidly refine auditory representation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.