ArticleCirculation research2014
Abi3bp regulates cardiac progenitor cell proliferation and differentiation.
Article in Circulation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Syn III participated in rTMS-modulated emotional rescue in the prefrontal cortex under simulated space composite environment.Molecular psychiatry · 2026Article
- Age-Related Transcriptomic Changes in the Vermiform Appendix.International journal of molecular sciences · 2025Article
- ABI3BP can inhibit the proliferation, invasion, and epithelial-mesenchymal transition of non-small-cell lung cancer cells.Open life sciences · 2025Article
- Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk.Antioxidants (Basel, Switzerland) · 2023Article
- Endothelial β1 Integrin-Mediated Adaptation to Myocardial Ischemia.Thrombosis and haemostasis · 2021Article
- The role of Sfrp and DKK proteins in cardiomyocyte development.Physiological reports · 2021Review
- Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells.Journal of experimental & clinical cancer research : CR · 2019Article
- The Extracellular Matrix Protein ABI3BP in Cardiovascular Health and Disease.Frontiers in cardiovascular medicine · 2019Review
- A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans.Psychiatry research · 2018Article
- Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition.Journal of molecular and cellular cardiology · 2018Article
- Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility.American journal of respiratory cell and molecular biology · 2017Article
- Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery.Pharmacology & therapeutics · 2017Review
- Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.Scientific reports · 2016Article
- Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology.Circulation research · 2016Review
- An integrated statistical model for enhanced murine cardiomyocyte differentiation via optimized engagement of 3D extracellular matrices.Scientific reports · 2015Article
- MicroRNAs and Cardiac Regeneration.Circulation research · 2015Review
- Extracellular Matrix Regulation of Stem Cell Behavior.Current stem cell reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
rationaleCardiac progenitor cells (CPCs) are thought to differentiate into the major cell types of the heart: cardiomyocytes, smooth muscle cells, and endothelial cells. We have recently identified ABI family, member 3 (NESH) binding protein (Abi3bp) as a protein important for mesenchymal stem cell biology. Because CPCs share several characteristics with mesenchymal stem cells, we hypothesized that Abi3bp would similarly affect CPC differentiation and proliferation.
objectiveTo determine whether Abi3bp regulates CPC proliferation and differentiation. METHODS AND
resultsIn vivo, genetic ablation of the Abi3bp gene inhibited CPC differentiation, whereas CPC number and proliferative capacity were increased. This correlated with adverse recovery after myocardial infarction. In vitro, CPCs, either isolated from Abi3bp knockout mice or expressing an Abi3bp shRNA construct, displayed a higher proliferative capacity and, under differentiating conditions, reduced expression of both early and late cardiomyocyte markers. Abi3bp controlled CPC differentiation via integrin-β1, protein kinase C-ζ, and v-akt murine thymoma viral oncogene homolog.
conclusionsWe have identified Abi3bp as a protein important for CPC differentiation and proliferation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.