ReviewMovement disorders : official journal of the Movement Disorder Society2015
Effects of levodopa on regional cerebral metabolism and blood flow.
Review in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Elevated cerebral oxygen extraction fraction in Parkinson's disease correlates with motor impairment severity.Scientific reports · 2026Article
- Cerebral perfusion imaging predicts levodopa-induced dyskinesia in Parkinsonian rat model.NPJ Parkinson's disease · 2025Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- Spatiotemporal patterns of brain iron-oxygen metabolism in patients with Parkinson's disease.European radiology · 2024Article
- Positron emission tomography neuroimaging of [Frontiers in neuroscience · 2024Article
- Functional brain networks in the evaluation of patients with neurodegenerative disorders.Nature reviews. Neurology · 2023Review
- Aberrant inter-network functional connectivity in drug-naive Parkinson's disease patients with tremor dominant and postural instability and gait difficulty.Frontiers in human neuroscience · 2023Article
- Differences in Striatal Metabolism in [Diagnostics (Basel, Switzerland) · 2022Article
- Predicting cognitive decline in Parkinson's disease using FDG-PET-based supervised learning.The Journal of clinical investigation · 2022Article
- Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson's Disease.Molecules (Basel, Switzerland) · 2021Review
- Spectral guided sparse inverse covariance estimation of metabolic networks in Parkinson's disease.NeuroImage · 2021Article
- Elevated caudate connectivity in cognitively normal Parkinson's disease patients.Scientific reports · 2020Article
- Preservation of brain metabolism in recently diagnosed Parkinson's impulse control disorders.European journal of nuclear medicine and molecular imaging · 2020Article
- Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson's disease.Parkinsonism & related disorders · 2020Article
- Abnormal pattern of brain glucose metabolism in Parkinson's disease: replication in three European cohorts.European journal of nuclear medicine and molecular imaging · 2020Article
- Blood-Brain Barrier Leakage Is Increased in Parkinson's Disease.Frontiers in physiology · 2020Article
- Brain-transportable dipeptides across the blood-brain barrier in mice.Scientific reports · 2019Article
- Blood Flow and Glucose Metabolism Dissociation in the Putamen Is Predictive of Levodopa Induced Dyskinesia in Parkinson's Disease Patients.Frontiers in neurology · 2019Article
- Imaging Markers of Progression in Parkinson's Disease.Movement disorders clinical practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Levodopa (L-dopa) has been at the forefront of antiparkinsonian therapy for a half century. Recent advances in functional brain imaging have contributed substantially to the understanding of the effects of L-dopa and other dopaminergic treatment on the activity of abnormal motor and cognitive brain circuits in Parkinson's disease patients. Progress has also been made in understanding the functional pathology of dyskinesias, a common side effect of l-dopa treatment, at both regional and network levels. Here, we review these studies, focusing mainly on the new mechanistic insights provided by metabolic brain imaging and network analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.