Evidence map›Paper›PMID 25296862›Full record

ArticleCirculation. Heart failure2014

Calcium channel blockers and outcomes in older patients with heart failure and preserved ejection fraction.

Kanan Patel, Gregg C Fonarow, Momanna Ahmed, Charity Morgan, Meredith Kilgore, Thomas E Love, Prakash Deedwania, Wilbert S Aronow, Stefan D Anker, Ali Ahmed

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Comparison of beta-blockersWorld journal of cardiology · 2025
    Article
  5. Article
  6. Observational
  7. Article
  8. Drug Therapy for Acute and Chronic Heart Failure with Preserved Ejection Fraction with Hypertension: A State-of-the-Art Review.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Trends in pharmacotherapy utilization among patients with heart failure with preserved ejection fraction.American heart journal plus : cardiology research and practice · 2023
    Article
  14. Current Management of Heart Failure with Preserved Ejection Fraction.The International journal of angiology : official publication of the International College of Angiology, Inc · 2022
    Article
  15. Amiodarone is associated with increased short-term mortality in elderly atrial fibrillation patients with preserved ejection fraction.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022
    Article
  16. Managing heart failure with preserved ejection fraction.Annals of translational medicine · 2020
    Review
  17. Review
  18. Review
  19. Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
    Review
  20. Targeting CaFrontiers in physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kanan PatelFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Gregg C FonarowFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Momanna AhmedFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Charity MorganFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Meredith KilgoreFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Thomas E LoveFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Prakash DeedwaniaFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Wilbert S AronowFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Stefan D AnkerFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.).
Ali AhmedFrom the Department of Medicine, University of California, San Francisco (K.P.); Division of Cardiology, University of California, Los Angeles (G.C.F.); Comprehensive Center for Healthy Aging (M.A.), Department of Biostatistics (C.M.) and Department of Health Care Organization and Policy (M.K.), School of Public Health, University of Alabama at Birmingham (M.A., C.M., M.K.); Department of Medicine, Case Western Reserve University, Cleveland, OH (T.E.L.); Department of Medicine, University of California, San Francisco, Fresno (P.D.); Department of Medicine, New York Medical College, Valhalla, NY (W.S.A.); Department of Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany (S.D.A.); Center for Health and Aging, Veterans Affairs Medical Center, Washington, DC (A.A.). aliahmedmdmph@gmail.com.
University of California, San Francisco · USCase Western Reserve University · USUniversity of California, Los Angeles · USNew York Medical College · US

Funding

Neurohormonal Blockade and Outcomes in Diastolic Heart FailureR01HL097047 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHMED, ALI · 2009 to 2010
$915k
NHLBI NIH HHS R01 HL097047NHLBI NIH HHS R01-HL097047
6 · The paper itself

Abstract

backgroundLittle is known about associations of calcium channel blockers (CCBs) with outcomes in patients with heart failure and preserved ejection fraction (EF). METHODS AND

resultsOf the 10 570 hospitalized patients with heart failure and preserved EF, ≥65 years, EF ≥40%, in the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF; 2003-2004), linked to Medicare data (through December 31, 2008), 7514 had no prior history of CCB use. Of these, 815 (11%) patients received new discharge prescriptions for CCBs. Propensity scores for CCB initiation, calculated for each of the 7514 patients, were used to assemble a matched cohort of 1620 (810 pairs) patients (mean age, 80 years; mean EF, 56%; 65% women; 10% black) receiving and not receiving CCBs, balanced on 114 baseline characteristics. The primary composite end point of all-cause mortality or heart failure hospitalization occurred in 82% and 81% of patients receiving and not receiving CCBs (hazard ratio for CCBs, 1.03; 95% confidence interval, 0.92-1.14). Hazard ratios (95% confidence intervals) for all-cause mortality, heart failure hospitalization, and all-cause hospitalization were 1.05 (0.94-1.18), 1.05 (0.91-1.21), and 1.03 (0.93-1.14), respectively. Similar associations were observed when we categorized patients into those receiving amlodipine and nonamlodipine CCBs. Among 7514 prematch patients, multivariable-adjusted and propensity-adjusted hazard ratios (95% confidence interval) for primary composite end point were 1.03 (0.95-1.12) and 1.02 (0.94-1.11), respectively.

conclusionsIn hospitalized older patients with heart failure, new discharge prescriptions for CCBs had no associations with composite or individual end points of mortality or heart failure hospitalization, regardless of the class of CCBs.

Indexed as

AgedAged, 80 and overCalcium Channel BlockersFemaleHeart FailureHospitalizationHumansMalePropensity ScoreStroke VolumeTreatment OutcomeCalcium Channel Blockerscalcium channel blockersheart failure

Identifiers

PMID25296862
PMCPMC4997614
OpenAlexW2135385506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.