ArticleMolecular plant2014
Age-triggered and dark-induced leaf senescence require the bHLH transcription factors PIF3, 4, and 5.
Article in Molecular plant, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 262 citations in OpenAlex.
- The plant longevity gene AHL15 delays leaf senescence by repressing ORESARA1 and cytokinin degradation.The Plant journal : for cell and molecular biology · 2026Article
- CabHLH18-like Gene Promotes Leaf Yellowing and Directly ActivatesPlants (Basel, Switzerland) · 2026Article
- SnRK2.4 and SnRK2.10 redundantly control developmental leaf senescence by sustaining ABA production and signaling.Plant physiology · 2026Article
- Leaf aging reduces photosynthetic and stomatal kinetics under fluctuating irradiance, but not steady-state traits.The Plant journal : for cell and molecular biology · 2026Article
- Functional conservation and diversity of phytochrome B and its potential applications in crop improvement.Plant communications · 2026Review
- Exploring wild rices for photosynthetic efficiency improvement in rice.Physiology and molecular biology of plants : an international journal of functional plant biology · 2026Article
- Mechanisms underlying green flower formation.Horticulture research · 2026Article
- DIVARICATA1 Promotes Leaf Degreening and Senescence in Arabidopsis.Plants (Basel, Switzerland) · 2026Article
- Genetic Mapping and Functional Characterisation of GhCUP Regulating Leaf Curling in Cotton.Plant biotechnology journal · 2026Article
- Regulatory Role of Jasmonate Signaling in Dark-, Drought-, and Salt-Induced Leaf Senescence.International journal of molecular sciences · 2026Review
- Multifaceted roles of SCRM/ICE1 in stomatal development, cold stress and beyond.Frontiers in plant science · 2026Review
- Effects of monochromatic red and blue light on photosynthetic efficiency and nutritional quality in Chinese kale microgreens.Frontiers in plant science · 2026Article
- HOS15 together with PWR-HDA9 positively regulates dark-induced senescence in Arabidopsis.Plant signaling & behavior · 2025Article
- Genome-Wide Isoform Switching Reveals SR45-Mediated Splicing Control ofInternational journal of molecular sciences · 2025Article
- Pulses of low-intensity red light inhibit the expression of chlorophyll degradation genes during postharvest senescence of kale leaves.Molecular biology reports · 2025Article
- Parasitic-Plant Parasite Rewires Flowering Pathways to Induce Stem-Derived Galls.Plant direct · 2025Article
- Regulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway.Journal of integrative plant biology · 2025Review
- NAC047/052/104 Synergistically Regulate the Dark-Induced Leaf Senescence in Non-Heading Chinese Cabbage.International journal of molecular sciences · 2025Article
- Transcription factors MdEIL1 and MdHY5 integrate ethylene and light signaling to promote chlorophyll degradation in mature apple peels.Horticulture research · 2025Article
- Circadian clock regulation in soybean senescence: a transcriptome analysis of early and late senescence types.BMC genomics · 2025Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Leaf senescence can be triggered and promoted by a large number of developmental and environmental factors. Numerous lines of evidence have suggested an involvement of phytochromes in the regulation of leaf senescence, but the related signaling pathways and physiological mechanisms are poorly understood. In this study, we initially identified phytochrome-interacting factors (PIFs) 3, 4, and 5 as putative mediators of leaf senescence. Mutations of the PIF genes resulted in a significantly enhanced leaf longevity in age-triggered and dark-induced senescence, whereas overexpressions of these genes accelerated age-triggered and dark-induced senescence in Arabidopsis. Consistently, loss-of-function of PIF4 attenuated dark-induced transcriptional changes associated with chloroplast deterioration and reactive oxygen species (ROS) generation. ChIP-PCR and Dual-Luciferase assays demonstrated that PIF4 can activate chlorophyll degradation regulatory gene NYE1 and repress chloroplast activity maintainer gene GLK2 by binding to their promoter regions. Finally, dark-induced ethylene biosynthesis and ethylene-induced senescence were both dampened in pif4, suggesting the involvement of PIF4 in both ethylene biosynthesis and signaling pathway. Our study provides evidence that PIF3, 4, and 5 are novel positive senescence mediators and gains an insight into the mechanism of light signaling involved in the regulation of leaf senescence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.