ArticleBiophysical journal2014
Structure-function relations and rigidity percolation in the shear properties of articular cartilage.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 97 citations in OpenAlex.
- Shear Strain Stiffening in Cartilage is Governed by a Mechanical Phase Transition.bioRxiv : the preprint server for biology · 2026Article
- Astral architecture can enhance mechanical strength of cytoskeletal networks by modulating percolation thresholds.Biophysical journal · 2026Article
- Shear Mechanics of Articular Cartilage and Cartilage-Inspired Materials.Annual review of condensed matter physics · 2026Article
- Delayed Lubricin Injection Improves Cartilage Repair Tissue Quality in an In Vivo Rabbit Osteochondral Defect Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Local shear properties of rabbit articular cartilage capture surface region mechanics of human, equine, and bovine tissue.Journal of biomechanics · 2025Article
- An open-source membrane stretcher for simultaneous mechanical and structural characterizations of soft materials and biological tissues.HardwareX · 2024Article
- An Open-Source Membrane Stretcher for Simultaneous Mechanical and Structural Characterizations of Soft Materials and Biological Tissues.bioRxiv : the preprint server for biology · 2024Article
- Review
- MRI-based degeneration grades for lumbar facet joints do not correlate with cartilage mechanics.JOR spine · 2023Article
- Pre-glycation impairs gelation of high concentration collagen solutions.Journal of biomedical materials research. Part A · 2022Article
- Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging.Nature communications · 2022Article
- Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions.Bioactive materials · 2022Review
- Structural origins of cartilage shear mechanics.Science advances · 2022Article
- Active cytoskeletal composites display emergent tunable contractility and restructuring.Soft matter · 2021Article
- Phase transitions in biology: from bird flocks to population dynamics.Proceedings. Biological sciences · 2021Article
- Percolation networks inside 3D model of the mineralized collagen fibril.Scientific reports · 2021Article
- Non-Destructive Spatial Mapping of Glycosaminoglycan Loss in Native and Degraded Articular Cartilage Using Confocal Raman Microspectroscopy.Frontiers in bioengineering and biotechnology · 2021Article
- Imaging the local biochemical content of native and injured intervertebral disc using Fourier transform infrared microscopy.JOR spine · 2020Article
- Role of Entropy in Colloidal Self-Assembly.Entropy (Basel, Switzerland) · 2020Review
- Mitoprotective therapy prevents rapid, strain-dependent mitochondrial dysfunction after articular cartilage injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Among mammalian soft tissues, articular cartilage is particularly interesting because it can endure a lifetime of daily mechanical loading despite having minimal regenerative capacity. This remarkable resilience may be due to the depth-dependent mechanical properties, which have been shown to localize strain and energy dissipation. This paradigm proposes that these properties arise from the depth-dependent collagen fiber orientation. Nevertheless, this structure-function relationship has not yet been quantified. Here, we use confocal elastography, quantitative polarized light microscopy, and Fourier-transform infrared imaging to make same-sample measurements of the depth-dependent shear modulus, collagen fiber organization, and extracellular matrix concentration in neonatal bovine articular cartilage. We find weak correlations between the shear modulus |G(∗)| and both the collagen fiber orientation and polarization. We find a much stronger correlation between |G(∗)| and the concentration of collagen fibers. Interestingly, very small changes in collagen volume fraction vc lead to orders-of-magnitude changes in the modulus with |G(∗)| scaling as (vc - v0)(ξ). Such dependencies are observed in the rheology of other biopolymer networks whose structure exhibits rigidity percolation phase transitions. Along these lines, we propose that the collagen network in articular cartilage is near a percolation threshold that gives rise to these large mechanical variations and localization of strain at the tissue's surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.