ArticleBrain connectivity2015
Quantitative Analysis of Myelin and Axonal Remodeling in the Uninjured Motor Network After Stroke.
Article in Brain connectivity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Low-frequency rTMS in patients with subacute ischemic stroke: clinical evaluation of short and long-term outcomes and neurophysiological assessment of cortical excitability.Journal of medicine and lifeTrial
- Mapping brain-behavior networks using functional and structural connectome fingerprinting in the HCP dataset.Brain and behavior · 2020Article
- Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging.Psychiatry research. Neuroimaging · 2020Article
- Magnetic Resonance Imaging as a Biomarker in Rodent Peripheral Nerve Injury Models Reveals an Age-Related Impairment of Nerve Regeneration.Scientific reports · 2019Article
- Brain networks and their relevance for stroke rehabilitation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Review
- Predicting Motor Outcomes in Stroke Patients Using Diffusion Spectrum MRI Microstructural Measures.Frontiers in neurology · 2019Article
- Quantitative assessment of demyelination in ischemic stroke in vivo using macromolecular proton fraction mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Advances in noninvasive myelin imaging.Developmental neurobiology · 2018Review
- On the Viability of Diffusion MRI-Based Microstructural Biomarkers in Ischemic Stroke.Frontiers in neuroscience · 2018Article
- Synergistic but independent: The role of corticospinal and alternate motor fibers for residual motor output after stroke.NeuroImage. Clinical · 2017Article
- Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct.Brain and behavior · 2017Article
- Ensemble average propagator-based detection of microstructural alterations after stroke.International journal of computer assisted radiology and surgery · 2016Article
- Structural connectivity analyses in motor recovery research after stroke.Annals of clinical and translational neurology · 2016Review
- Advanced neuroimaging applied to veterans and service personnel with traumatic brain injury: state of the art and potential benefits.Brain imaging and behavior · 2015Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Contralesional brain connectivity plasticity was previously reported after stroke. This study aims at disentangling the biological mechanisms underlying connectivity plasticity in the uninjured motor network after an ischemic lesion. In particular, we measured generalized fractional anisotropy (GFA) and magnetization transfer ratio (MTR) to assess whether poststroke connectivity remodeling depends on axonal and/or myelin changes. Diffusion-spectrum imaging and magnetization transfer MRI at 3T were performed in 10 patients in acute phase, at 1 and 6 months after stroke, which was affecting motor cortical and/or subcortical areas. Ten age- and gender-matched healthy volunteers were scanned 1 month apart for longitudinal comparison. Clinical assessment was also performed in patients prior to magnetic resonance imaging (MRI). In the contralesional hemisphere, average measures and tract-based quantitative analysis of GFA and MTR were performed to assess axonal integrity and myelination along motor connections as well as their variations in time. Mean and tract-based measures of MTR and GFA showed significant changes in a number of contralesional motor connections, confirming both axonal and myelin plasticity in our cohort of patients. Moreover, density-derived features (peak height, standard deviation, and skewness) of GFA and MTR along the tracts showed additional correlation with clinical scores than mean values. These findings reveal the interplay between contralateral myelin and axonal remodeling after stroke.
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Registered trials
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