Evidence map›Paper›PMID 25295933›Full record

ArticleNature medicine2014

Reply: the BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia.

S Tiong Ong, Charles T H Chuah, Tun Kiat Ko, Axel M Hillmer, Wan-Teck Lim

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. The pharmacogenomics of drug resistance to protein kinase inhibitors.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2016
    Review
  5. Review
  6. Impact of theJournal of global oncology · 2016
    Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

S Tiong Ong1] Cancer &Stem Cell Biology Signature Research Programme, Duke-National University of Singapore Graduate Medical School, Singapore. [2] Department of Haematology, Singapore General Hospital, Singapore. [3] Department of Medical Oncology, National Cancer Centre, Singapore. [4] Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Charles T H Chuah1] Cancer &Stem Cell Biology Signature Research Programme, Duke-National University of Singapore Graduate Medical School, Singapore. [2] Department of Haematology, Singapore General Hospital, Singapore.
Tun Kiat KoCancer &Stem Cell Biology Signature Research Programme, Duke-National University of Singapore Graduate Medical School, Singapore.
Axel M HillmerCancer Therapeutics &Stratified Oncology, Genome Institute of Singapore, Singapore.
Wan-Teck LimDepartment of Medical Oncology, National Cancer Centre, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ApoptosisApoptosis Regulatory ProteinsCarcinoma, Non-Small-Cell LungDrug Resistance, NeoplasmFemaleHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLung NeoplasmsMaleMembrane ProteinsPolymorphism, GeneticProtein Kinase InhibitorsProto-Oncogene ProteinsSequence DeletionApoptosis Regulatory ProteinsMembrane ProteinsProtein Kinase InhibitorsProto-Oncogene Proteins

Identifiers

PMID25295933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.