ArticlePloS one2014
Importance of reciprocal balance of T cell immunity in Mycobacterium abscessus complex lung disease.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
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- Early IL-17A production helps establish Mycobacterium intracellulare infection in mice.PLoS pathogens · 2022Article
- Virulence Mechanisms ofFrontiers in microbiology · 2022Review
- Host-Pathogen Interactions Operative duringImmune network · 2021Review
- Immune defects in patients with pulmonaryERJ open research · 2020Article
- A New Model of ChronicInternational journal of molecular sciences · 2020Article
- Characteristics of Circulating CD4Journal of clinical medicine · 2020Article
- The Rise of Non-Tuberculosis Mycobacterial Lung Disease.Frontiers in immunology · 2020Review
- BCG Vaccination InducesFrontiers in immunology · 2019Article
- Anomalies in T Cell Function Are Associated With Individuals at Risk ofFrontiers in immunology · 2018Article
- Article
- Down-Regulation of Serum High-Mobility Group Box 1 Protein in Patients with Pulmonary Tuberculosis and Nontuberculous Mycobacterial Lung Disease.Tuberculosis and respiratory diseases · 2017Article
- An in vitro model of granuloma-like cell aggregates substantiates early host immune responses against Mycobacterium massiliense infection.Biology open · 2016Article
- Mycobacterium tuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses.Medical microbiology and immunology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the nature of the host immune response to Mycobacterium abscessus complex (MABC) infection. The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics.
methodsA total of 22 immunomolecules in 24 MABC lung disease patients before and after antibiotic therapy were quantitatively analyzed using a multiplex bead-based system.
resultsIn general, the pre-treatment levels of T helper type 1 (Th1)-related cytokines, i.e., interferon (IFN)-γ and interleukin (IL)-12, and Th2-related cytokines, i.e., IL-4 and IL-13, were significantly decreased in patients compared with control subjects. In contrast, the pre-treatment levels of Th17-related cytokines, i.e., IL-17 and IL-23, were significantly increased in MABC patients. Interestingly, significantly higher levels of IFN-γ-induced protein (IP)-10 and monokine induced by IFN-γ protein (MIG) were detected in patients with failure of sputum conversion at post-treatment compared to patients with successful sputum conversion.
conclusionReduced Th1 and Th2 responses and enhanced Th17 responses in patients may perpetuate MABC lung disease, and the immunomolecules IP-10 and MIG, induced through IFN-γ, may serve as key markers for indicating the treatment outcome.
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