ArticleThe Journal of organic chemistry2014
Interstrand cross-link and bioconjugate formation in RNA from a modified nucleotide.
Article in The Journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Generation of oligonucleotide conjugatesChemical science · 2022Article
- Trapping Transient RNA Complexes by Chemically Reversible Acylation.Angewandte Chemie (International ed. in English) · 2020Article
- Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate.Bioorganic & medicinal chemistry · 2018Article
- Synthesis of native-like crosslinked duplex RNA and study of its properties.Bioorganic & medicinal chemistry · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
RNA oligonucleotides containing a phenyl selenide derivative of 5-methyluridine were chemically synthesized by solid-phase synthesis. The phenyl selenide is rapidly converted to an electrophilic, allylic phenyl seleneate under mild oxidative conditions. The phenyl seleneate yields interstrand cross-links when part of a duplex and is useful for synthesizing oligonucleotide conjugates. Formation of the latter is illustrated by reaction of an oligonucleotide containing the phenyl selenide with amino acids in the presence of mild oxidant. The products formed are analogous to those observed in tRNA that are believed to be formed posttranslationally via a biosynthetic intermediate that is chemically homologous to the phenyl seleneate.
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Registered trials
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