ArticleCell metabolism2014
Muscle over mind.
Article in Cell metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis.Molecular neurobiology · 2021Article
- Understanding stress: Insights from rodent models.Current research in neurobiology · 2021Review
- Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2.Frontiers in physiology · 2021Article
- Neural maturation enhanced by exercise-induced extracellular derivatives.Scientific reports · 2020Article
- Revisiting the Stress Concept: Implications for Affective Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Impaired Skeletal Muscle Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2019Article
- The Potential Mechanisms of Exercise-induced Cognitive Protection: A Literature Review.Current pharmaceutical design · 2018Review
- Can physical exercise in old age improve memory and hippocampal function?Brain : a journal of neurology · 2016Review
- The current state of physical activity and exercise programs in German-speaking, Swiss psychiatric hospitals: results from a brief online survey.Neuropsychiatric disease and treatment · 2016Article
- Exercise-mimetic AICAR transiently benefits brain function.Oncotarget · 2015Article
- The Magic of Movement; the Potential of Exercise to Improve Cognition.Schizophrenia bulletin · 2015Article
- Role of physical and mental training in brain network configuration.Frontiers in aging neuroscience · 2015Review
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Depression is associated with elevated kynurenine levels, a tryptophan metabolite generated under stress and inflammatory conditions. Agudelo et al. (2014) now reveal how PGC-1α1 overexpression in muscle mimics anti-depressant effects of exercise by promoting kynurenine aminotransferase expression, likely preventing kynurenine from crossing the blood brain barrier to disrupt neural plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.