ArticleJournal of the American Chemical Society2014
Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
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- The impact of tropodithietic acid on microbial physiology under varying culture complexities.mSphere · 2025Article
- Iron limitation triggers roseoceramide biosynthesis and membrane remodeling in marine roseobacter.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exchange or Eliminate: The Secrets of Algal-Bacterial Relationships.Plants (Basel, Switzerland) · 2024Review
- The Small-Molecule Language of Dynamic Microbial Interactions.Annual review of microbiology · 2022Review
- Associated bacterial microbiome responds opportunistic once algal host Scenedesmus vacuolatus is attacked by endoparasite Amoeboaphelidium protococcarum.Scientific reports · 2022Article
- Algal p-coumaric acid induces oxidative stress and siderophore biosynthesis in the bacterial symbiont Phaeobacter inhibens.Cell chemical biology · 2022Article
- Bacterial diversity in different outdoor pilot plant photobioreactor types during production of the microalga Nannochloropsis sp. CCAP211/78.Applied microbiology and biotechnology · 2022Article
- Structural Elucidation of Cryptic Algaecides in Marine Algal-Bacterial Symbioses by NMR Spectroscopy and MicroED.Angewandte Chemie (International ed. in English) · 2022Article
- Algicidal Bacteria: A Review of Current Knowledge and Applications to Control Harmful Algal Blooms.Frontiers in microbiology · 2022Review
- Sex plays a role in the construction of epiphytic bacterial communities on the algal bodies and receptacles ofFrontiers in microbiology · 2022Article
- Long-Term Survival ofmBio · 2021Article
- A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters.Annual review of biochemistry · 2021Review
- Temperature Stress Induces Shift From Co-Existence to Competition for Organic Carbon in Microalgae-Bacterial Photobioreactor Community - Enabling Continuous Production of Microalgal Biomass.Frontiers in microbiology · 2021Article
- Bacterial Tropone Natural Products and Derivatives: Overview of their Biosynthesis, Bioactivities, Ecological Role and Biotechnological Potential.Chembiochem : a European journal of chemical biology · 2020Review
- Amino Acid and Sugar Catabolism in the Marine Bacterium Phaeobacter inhibens DSM 17395 from an Energetic Viewpoint.Applied and environmental microbiology · 2019Article
- The effect of the algal microbiome on industrial production of microalgae.Microbial biotechnology · 2018Review
- Synergistic activity of cosecreted natural products from amoebae-associated bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Novel Microbial Culture Chamber Co-cultivation System to Study Algal-Bacteria Interactions UsingFrontiers in microbiology · 2018Article
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4 authors at 1 institution in 1 country.
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Abstract
Roseobacticides regulate the symbiotic relationship between a marine bacterium (Phaeobacter inhibens) and a marine microalga (Emiliania huxleyi). This relationship can be mutualistic, when the algal host provides food for the bacteria and the bacteria produce growth hormones and antibiotics for the algae, or parasitic, when the algae senesce and release p-coumaric acid. The released p-coumaric acid causes the bacteria to synthesize roseobacticides, which are nM-μM toxins for the algae. We examined the biosynthesis of roseobacticides and report that all roseobacticide precursors play critical roles during the mutualist phase of the symbiosis. Roseobacticides are biosynthesized from the algal growth promoter, the major food molecule provided by the algal cells, and the algal senescence signal that initiates the mutualist-to-parasite switch. Thus, molecules that are beneficial during mutualism are diverted to the synthesis of toxins during parasitism. A plausible mechanism for assembling roseobacticides from these molecules is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.