ArticleBioMed research international2014
Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Real-time monitoring and quantitative analysis of PAG-mediated chemical cochleostomy using 1.06-µm swept-source optical coherence tomography.Biomedical optics express · 2026Article
- Real-time closed-loop tissue-specific laser osteotomy using deep-learning-assisted optical coherence tomography.Biomedical optics express · 2023Article
- Towards OCT-Guided Endoscopic Laser Surgery-A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths.Biomedical optics express · 2021Article
- Continuous Feature-Based Tracking of the Inner Ear for Robot-Assisted Microsurgery.Frontiers in surgery · 2021Article
- Spatio-temporal deep learning methods for motion estimation using 4D OCT image data.International journal of computer assisted radiology and surgery · 2020Article
- Concept for Markerless 6D Tracking Employing Volumetric Optical Coherence Tomography.Sensors (Basel, Switzerland) · 2020Article
- High-resolution Imaging of the Human Cochlea through the Round Window by means of Optical Coherence Tomography.Scientific reports · 2019Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Remote photoacoustic sensing using speckle-analysis.Scientific reports · 2019Article
- Feasibility Assessment of Optical Coherence Tomography-Guided Laser Labeling in Middle Cranial Fossa Approach.Iranian journal of otorhinolaryngology · 2018Article
- Outlook and future of inner ear therapy.Hearing research · 2018Review
- Comparative microstructural analysis of bone osteotomies after cutting by computer-assisted robot-guided laser osteotome and piezoelectric osteotome: an in vivo animal study.Lasers in medical science · 2018Article
- Review of intraoperative optical coherence tomography: technology and applications [Invited].Biomedical optics express · 2017Article
- High-speed OCT light sources and systems [Invited].Biomedical optics express · 2017Review
- Experimental Visualization of Labyrinthine Structure with Optical Coherence Tomography.Iranian journal of otorhinolaryngology · 2017Article
- Laser Bone Shaping: Current Capabilities and Future Applications in Knee Arthroplasty.JB & JS open accessReview
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lasers have been proven to be precise tools for bone ablation. Applying no mechanical stress to the patient, they are potentially very suitable for microsurgery on fragile structures such as the inner ear. However, it remains challenging to control the laser-bone ablation without injuring embedded soft tissue. In this work, we demonstrate a closed-loop control of a short-pulsed CO2 laser to perform laser cochleostomy under the monitoring of an optical coherence tomography (OCT) system. A foresighted detection of the bone-endosteum-perilymph boundary several hundred micrometers before its exposure has been realized. Position and duration of the laser pulses are planned based on the residual bone thickness distribution. OCT itself is also used as a highly accurate tracking system for motion compensation between the target area and the optics. During ex vivo experimental evaluation on fresh porcine cochleae, the ablation process terminated automatically when the thickness of the residual tissue layer uniformly reached a predefined value. The shape of the resulting channel bottom converged to the natural curvature of the endosteal layer without injuring the critical structure. Preliminary measurements in OCT scans indicated that the mean absolute accuracy of the shape approximation was only around 20 μm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.