ArticleBioMed research international2014
Age dependent differences in collagen alignment of glutaraldehyde fixed bovine pericardium.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Identification of Autologous Tissue Sources and Optimization of a Treatment Method for Intraoperative Manufacturing of Heart Valve Constructs.Artificial organs · 2026Article
- Biomechanical Assessment Using MRI of Custom-Made Bovine Pericardial Tubes as Potential Aortic Replacements.Radiology research and practice · 2026Article
- Tissue requirements for the application of aortic valve neocuspidization - appropriate pericardium properties and homogeneity?Journal of materials science. Materials in medicine · 2024Article
- Characterization of a decellularized pericardium extracellular matrix hydrogel for regenerative medicine: insights on animal-to-animal variability.Frontiers in bioengineering and biotechnology · 2024Article
- Pericardial effusion and tamponade in the context of herpes zoster: a novel occurrence.European heart journal. Case reports · 2023Article
- Article
- Collagen Fibril Orientation in Tissue Specimens From Atherosclerotic Plaque Explored Using Small Angle X-Ray Scattering.Journal of biomechanical engineering · 2022Article
- Article
- Yak Pericardium as an Alternative Biomaterial for Transcatheter Heart Valves.Frontiers in bioengineering and biotechnology · 2021Article
- Age-related dataset on the mechanical properties and collagen fibril structure of tendons from a murine model.Scientific data · 2018Article
- Structural characterization of four different naturally occurring porcine collagen membranes suitable for medical applications.PloS one · 2018Article
- Evaluation of transcatheter heart valve biomaterials: Biomechanical characterization of bovine and porcine pericardium.Journal of the mechanical behavior of biomedical materials · 2017Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties. Pericardium from neonatal animals (4-7 days old) is advantageously thinner and is considered as an alternative to that from adult animals. Here, the structures of adult and neonatal bovine pericardium tissues fixed with glutaraldehyde are characterized by synchrotron-based small angle X-ray scattering (SAXS) and compared with the mechanical properties of these materials. Significant differences are observed between adult and neonatal tissue. The glutaraldehyde fixed neonatal tissue has a higher modulus of elasticity (83.7 MPa) than adult pericardium (33.5 MPa) and a higher normalised ultimate tensile strength (32.9 MPa) than adult pericardium (19.1 MPa). Measured edge on to the tissue, the collagen in neonatal pericardium is significantly more aligned (orientation index (OI) 0.78) than that in adult pericardium (OI 0.62). There is no difference in the fibril diameter between neonatal and adult pericardium. It is shown that high alignment in the plane of the tissue provides the mechanism for the increased strength of the neonatal material. The superior strength of neonatal compared with adult tissue supports the use of neonatal bovine pericardium in heterografts.
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