Evidence map›Paper›PMID 25295224›Full record

ArticleBioinorganic reaction mechanisms2013

Texaphyrins and water-soluble zinc(II) ionophores: development, mechanism of anticancer activity, and synergistic effects.

Christian Preihs, Darren J Magda, Jonathan L Sessler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinorganic reaction mechanisms, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christian PreihsDepartment of Chemistry and Biochemistry, University of Texas, 105 East 24th Street, Stop A5300, Austin, TX 78712-1224, USA; and Advanced Imaging Research Center, University of Texas (UT) Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Darren J MagdaLumiphore, Inc., 604 Bancroft Way, Suite B, Berkeley, CA 94710, USA.
Jonathan L SesslerDepartment of Chemistry and Biochemistry, University of Texas, 105 E. 24th Street, Stop A5300, Austin, TX 78712-1224, USA; and Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Lumiphore (United States) · USThe University of Texas at Austin · US

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
NCI NIH HHS R01 CA068682
6 · The paper itself

Abstract

Texaphyrins, first prepared by Sessler and coworkers in the 1980s, represent early examples of expanded porphyrins. This class of pentaaza, oligopyrrolic macrocycles demonstrates excellent tumor localization and metal-chelating properties. In biological milieus, texaphyrins act as redox mediators and are able to produce reactive oxygen species. Furthermore, texaphyrins have been shown to upregulate zinc

Indexed as

expanded porphyrinsMRI contrast agentsporphyrinsradiation sensitizersreactive oxygen specieszinc ionophores

Identifiers

PMID25295224
PMCPMC4185204
OpenAlexW2077003328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.