Evidence map›Paper›PMID 25295103›Full record

ArticleOncology letters2014

Evaluation of immunohistochemistry using two different antibodies and procedures for primary lung adenocarcinoma harboring anaplastic lymphoma kinase rearrangement.

Jun Akiba, Akihiko Kawahara, Hideyuki Abe, Koichi Azuma, Tomohiko Yamaguchi, Tomoki Taira, Chihiro Fukumitsu, Yorihiko Takase, Makiko Yasumoto, Yumi Umeno and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Jun AkibaDepartment of Pathology, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Akihiko KawaharaDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Hideyuki AbeDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Koichi AzumaDepartment of Internal Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Tomohiko YamaguchiDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Tomoki TairaDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Chihiro FukumitsuDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Yorihiko TakaseDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Makiko YasumotoDepartment of Pathology, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Yumi UmenoDepartment of Pathology, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Keita TodorokiDepartment of Pathology, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Takashi KuritaDepartment of Pathology, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Rin YamaguchiDepartment of Pathology, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Masayoshi KageDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Hirohisa YanoDepartment of Pathology, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Kurume University Hospital · JPKurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rearrangements of anaplastic lymphoma kinase (ALK) have been recently identified in non-small cell lung carcinomas. Previous studies have revealed characteristic features, including adenocarcinoma histology and mucin production, in ALK-positive lung carcinoma. The present study evaluated immunohistochemistry (IHC) in ALK-positive lung carcinoma using two different antibodies, clone 5A4 and D5F3, and compared the results. On the basis of the aforementioned characteristic features, out of 359 primary lung carcinomas, the ALK status of 14 adenocarcinomas was screened using the intercalated antibody-enhanced polymer (iAEP) method with antibody 5A4, and this was compared with the ALK status obtained using rabbit monoclonal antibody D5F3 and fluorescence

Indexed as

adenocarcinomaanaplastic lymphoma kinasefluorescence in situ hybridizationimmunohistochemistrylung cancer

Identifiers

PMID25295103
PMCPMC4186587
OpenAlexW2047096633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.