ReviewFrontiers in immunology2014
Age-Dependent Immune Events during HBV Infection from Birth to Adulthood: An Alternative Interpretation.
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma.World journal of gastroenterology · 2017Trial
- Intrauterine exposure to HBsAg attenuates the immune response to hepatitis B vaccine via the miR-155-5p/MyD88 axis of DCs in mouse pups.Medical microbiology and immunology · 2026Article
- Indeterminate Phase/Grey Zone of Chronic Hepatitis B: Clinical Features, Outcomes and Molecular Insights.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- Chronic Hepatitis B Virus Infection Acquired Under Cytostatic Treatment in Childhood - Clinical, Virological and Immunological Long-Term Follow-Up.Journal of viral hepatitis · 2026Article
- Incidence and determinants of achieving HBsAg <100 IU/mL in HBeAg-negative CHB patients with nucleos(t)ide analogue treatment.Emerging microbes & infections · 2025Article
- Nucleos(t)ide Analog Treatment Discontinuation in Chronic Hepatitis B Virus Infection: A Systematic Literature Review.Gastro hep advances · 2025Review
- Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients.Frontiers in immunology · 2024Article
- Mendelian randomization of chronic hepatitis B and cardiovascular disease.Frontiers in cardiovascular medicine · 2024Article
- Review
- Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study.World journal of gastroenterology · 2021Article
- Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver.JCI insight · 2021Article
- Article
- Hepatitis B and Pregnancy: Virologic and Immunologic Characteristics.Hepatology communications · 2020Review
- Association between IL-37 gene polymorphisms and risk of HBV-related liver disease in a Saudi Arabian population.Scientific reports · 2019Article
- Identification of novel susceptibility loci associated with hepatitis B surface antigen seroclearance in chronic hepatitis B.PloS one · 2018Article
- Tolerance and immunity to pathogens in early life: insights from HBV infection.Seminars in immunopathology · 2017Review
- The Development ofFrontiers in immunology · 2017Article
- The role of tumour necrosis factor in hepatitis B infection: Jekyll and Hyde.Clinical & translational immunology · 2016Review
- Occult HBV Infection in Immunized Neonates Born to HBsAg-Positive Mothers: A Prospective and Follow-Up Study.PloS one · 2016Article
- New insights into the evolutionary rate of hepatitis B virus at different biological scales.Journal of virology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune responses change during the life of an individual. While this concept has been well accepted for adaptive immunity, only recently it is becoming clear that the innate immune responses also acquire distinct features in different phases of life. We believe that this concept can offer a different interpretation of the pathological manifestations that can be observed in HBV-infected subjects during the patient's life. Here, we will review the age-related immunopathological features of HBV infection and discuss how the different virological and clinical manifestations might be linked to the developmental pathway of the immune system from newborns to adults. We will discuss how the age of patients can affect the degree of inflammatory responses, but not the levels of antiviral specific immunity. We then propose that the different clinical manifestations occurring during the natural history of HBV infection are related to the host ability to trigger an inflammatory immune response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.