ArticleFrontiers in behavioral neuroscience2014
Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 32 citations in OpenAlex.
- Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation.Communications biology · 2024Article
- Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice.Acta pharmacologica Sinica · 2024Article
- Behavioral Effects of Buspirone in Juvenile Zebrafish of Two Different Genetic Backgrounds.Toxics · 2022Article
- Rnf220 is Implicated in the Dorsoventral Patterning of the Hindbrain Neural Tube in Mice.Frontiers in cell and developmental biology · 2022Article
- Valproate Reverses Mania-Like Behavior ofNeuropsychiatric disease and treatment · 2021Article
- Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Astrocytic Glutamate Transporter 1 (GLT1) Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice.Frontiers in behavioral neuroscience · 2020Article
- Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin.Neuroscience bulletin · 2019Article
- Differential Hippocampal Expression of BDNF Isoforms and Their Receptors Under Diverse Configurations of the Serotonergic System in a Mice Model of Increased Neuronal Survival.Frontiers in cellular neuroscience · 2019Article
- Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response.Frontiers in neuroscience · 2018Article
- Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis.Frontiers in cellular neuroscience · 2017Review
- Reducing central serotonin in adulthood promotes hippocampal neurogenesis.Scientific reports · 2016Article
- Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability.Frontiers in behavioral neuroscience · 2015Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Dysfunction of central serotonin (5-HT) system has been proposed to be one of the underlying mechanisms for anxiety and depression, and the association of diabetes mellitus and psychiatric disorders has been noticed by the high prevalence of anxiety/depression in patients with diabetes mellitus. This promoted us to examine these behaviors in central 5-HT-deficient mice and those also suffering with diabetes mellitus. Mice lacking either 5-HT or central serotonergic neurons were generated by conditional deletion of Tph2 or Lmx1b respectively. Simultaneous depletion of both central serotonergic neurons and pancreatic islet cells was achieved by administration of diphtheria toxin (DT) in Pet1-Cre;Rosa26-DT receptor (DTR) mice. The central 5-HT-deficient mice showed reduced anxiety-like behaviors as they spent more time in and entered more often into the light box in the light/dark box test compared with controls; similar results were observed in the elevated plus maze test. However, they displayed no differences in the immobility time of the forced swimming and tail suspension tests suggesting normal depression-like behaviors in central 5-HT-deficient mice. As expected, DT-treated Pet1-Cre;Rosa26-DTR mice lacking both central serotonergic neurons and pancreatic islet endocrine cells exhibited several classic diabetic symptoms. Interestingly, they displayed increased anxiety-like behaviors but reduced immobility time in the forced swimming and tail suspension tests. Furthermore, the hippocampal neurogenesis was dramatically enhanced in these mice. These results suggest that the deficiency of central 5-HT may not be sufficient to induce anxiety/depression-like behaviors in mice, and the enhanced hippocampal neurogenesis may contribute to the altered depression-like behaviors in the 5-HT-deficient mice with diabetes. Our current investigation provides understanding the relationship between diabetes mellitus and psychiatric disorders.
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