Evidence map›Paper›PMID 25294990›Full record

ArticleFrontiers in systems neuroscience2014

Mapping and morphometric analysis of synapses and spines on fusiform cells in the dorsal cochlear nucleus.

Rony H Salloum, Guoyou Chen, Liliya Velet, Nauman F Manzoor, Rachel Elkin, Grahame J Kidd, John Coughlin, Christopher Yurosko, Stephanie Bou-Anak, Shirin Azadi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Sparsely Distributed, Pre-synaptic Kv3 KFrontiers in cellular neuroscience · 2021
    Article
  3. Spontaneous Activity Defines Effective Convergence Ratios in an Inhibitory Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Rony H SalloumDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Guoyou ChenDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Liliya VeletDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Nauman F ManzoorDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Rachel ElkinDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Grahame J KiddDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
John CoughlinDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Christopher YuroskoDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Stephanie Bou-AnakDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Shirin AzadiDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Stephanie GohlschDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Harold SchneiderDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
James A KaltenbachDepartment of Neurosciences, Lerner Research Institute and Head and Neck Institute, Cleveland Clinic Cleveland, OH, USA.
Cleveland Clinic Lerner College of Medicine · US

Funding

Central auditory plasticity as a basis of tinnitusR01DC009097 · NIDCD · CLEVELAND CLINIC LERNER COM-CWRU · PI KALTENBACH, JAMES A · 2009 to 2013
$1.9M
NIDCD NIH HHS R01 DC009097
6 · The paper itself

Abstract

Fusiform cells are the main integrative units of the mammalian dorsal cochlear nucleus (DCN), collecting and processing inputs from auditory and other sources before transmitting information to higher levels of the auditory system. Despite much previous work describing these cells and the sources and pharmacological identity of their synaptic inputs, information on the three-dimensional organization and utltrastructure of synapses on these cells is currently very limited. This information is essential since an understanding of synaptic plasticity and remodeling and pathologies underlying disease states and hearing disorders must begin with knowledge of the normal characteristics of synapses on these cells, particularly those features that determine the strength of their influence on the various compartments of the cell. Here, we employed serial block face scanning electron microscopy (SBFSEM) followed by 3D reconstructions to map and quantitatively characterize synaptic features on DCN fusiform cells. Our results reveal a relative sparseness of synapses on the somata of fusiform cells but a dense distribution of synapses on apical and basal dendrites. Synapses on apical dendrites were smaller and more numerous than on basal dendrites. The vast majority of axosomatic terminals were found to be linked to other terminals connected by the same axon or different branches of the same axon, suggesting a high degree of divergent input to fusiform cells. The size of terminals was correlated with the number of mitochondria and with the number of active zones, which was highly correlated with the number of postsynaptic densities, suggesting that larger terminals exert more powerful influence on the cell than smaller terminals. These size differences suggest that the input to basal dendrites, most likely those from the auditory nerve, provide the most powerful sources of input to fusiform cells, while those to apical dendrites (e.g., parallel fiber) are weaker but more numerous.

Indexed as

active zonedendritic spine volumesdorsal cochlear nucleusfusiform cellsparallel fiberspostsynaptic densityserial block face scanning electron microscopysynaptic vesicles

Identifiers

PMID25294990
PMCPMC4172007
OpenAlexW2124129273

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.