ArticleDevelopment (Cambridge, England)2014
A theoretical framework for the regulation of Shh morphogen-controlled gene expression.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
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- The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt.Bulletin of mathematical biology · 2026Article
- Bifunctional transcriptional effector domains control gene expression pulses in an occupancy-dependent manner.bioRxiv : the preprint server for biology · 2025Article
- Stem cell-based approach to identify regulatory TFs during mammalian cell differentiation.Stem cell reports · 2025Article
- From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.Development (Cambridge, England) · 2025Review
- Dynamics of morphogen source formation in a growing tissue.PLoS computational biology · 2024Article
- A mathematical framework for measuring and tuning tempo in developmental gene regulatory networks.Development (Cambridge, England) · 2024Article
- The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level.Developmental cell · 2023Article
- Identification of non-coding silencer elements and their regulation of gene expression.Nature reviews. Molecular cell biology · 2023Review
- Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks.Science advances · 2023Article
- A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity.Neuroscience bulletin · 2023Review
- Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies.Developmental cell · 2023Article
- Elucidating multi-input processing 3-node gene regulatory network topologies capable of generating striped gene expression patterns.PLoS computational biology · 2022Article
- Multiple morphogens and rapid elongation promote segmental patterning during development.PLoS computational biology · 2021Article
- Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks.Development (Cambridge, England) · 2021Article
- Tractable nonlinear memory functions as a tool to capture and explain dynamical behaviors.Physical review research · 2020Article
- Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Species-specific pace of development is associated with differences in protein stability.Science (New York, N.Y.) · 2020Article
- Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch.Molecular systems biology · 2020Article
- Interplay between morphogen-directed positional information systems and physiological signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
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Abstract
How morphogen gradients govern the pattern of gene expression in developing tissues is not well understood. Here, we describe a statistical thermodynamic model of gene regulation that combines the activity of a morphogen with the transcriptional network it controls. Using Sonic hedgehog (Shh) patterning of the ventral neural tube as an example, we show that the framework can be used together with the principled parameter selection technique of approximate Bayesian computation to obtain a dynamical model that accurately predicts tissue patterning. The analysis indicates that, for each target gene regulated by Gli, which is the transcriptional effector of Shh signalling, there is a neutral point in the gradient, either side of which altering the Gli binding affinity has opposite effects on gene expression. This explains recent counterintuitive experimental observations. The approach is broadly applicable and provides a unifying framework to explain the temporospatial pattern of morphogen-regulated gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.