SynthesisCirculation. Heart failure2014
Clinical outcomes after continuous-flow left ventricular assist device: a systematic review.
Synthesis in Circulation. Heart failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Trial of a Shared Decision Support Intervention for Patients and Their Caregivers Offered Destination Therapy for End-Stage Heart Failure
Multi-Site Feasibility Testing of the Ventricular Assist Device Anticipatory Guidance Tool
Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Psychosocial outcomes in pediatric patients with ventricular assist devices and their families: A systematic review.Pediatric transplantation · 2021Pooled it
- Clinical effectiveness of therapy with continuous-flow left ventricular assist devices in nonischemic versus ischemic cardiomyopathy: a systematic review and meta-analysis.Canadian journal of surgery. Journal canadien de chirurgie · 2021Pooled it
- Stroke and Intracranial Hemorrhage in HeartMate II and HeartWare Left Ventricular Assist Devices: A Systematic Review.Neurocritical care · 2017Pooled it
- Industry sponsorship and research outcome.The Cochrane database of systematic reviews · 2017Pooled it
- Effectiveness of an Intervention Supporting Shared Decision Making for Destination Therapy Left Ventricular Assist Device: The DECIDE-LVAD Randomized Clinical Trial.JAMA internal medicine · 2018Trial
- Chinese Guidelines for the Diagnosis and Treatment of Heart Failure 2024.Journal of geriatric cardiology : JGC · 2025Article
- Linking Cardiac Psychology and Cardiovascular Medicine via Self-Determination Theory and Shared Decision-Making.Journal of clinical psychology in medical settings · 2025Review
- Transcatheter Aortic Valve Embolization in a Patient With a Left Ventricular Assist Device.CASE (Philadelphia, Pa.) · 2024Article
- Patient and parent-reported outcomes in paediatric ventricular assist device support: a multi-center ACTION learning network feasibility and pilot experience.Cardiology in the young · 2023Article
- Racial and Ethnic Disparities in Ambulatory Heart Failure Ventricular Assist Device Implantation and Survival.JACC. Heart failure · 2023Article
- Variation in Left Ventricular Assist Device Postdischarge Caregiver Requirements: Results From a Mixed-Methods Study With Equity Implications.Circulation. Heart failure · 2022Article
- Nontuberculous Mycobacterial Infections Associated With Left Ventricular Assist Devices in 3 Patients.Texas Heart Institute journal · 2022Review
- Contrast-Enhanced Ultrasound of Muscle Perfusion May Indicate Patient Response to Left Ventricular Assist Device Therapy.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021Article
- Evaluation of patients with a HeartMate 3 left ventricular assist device using echocardiographic particle image velocimetry.Journal of ultrasound · 2021Article
- Five-year outcomes following left ventricular assist device implantation in England.Open heart · 2021Article
- Contemporary outcomes of continuous-flow left ventricular assist devices-a systematic review.Annals of cardiothoracic surgery · 2021Article
- The Importance of Mental Models in Implementation Science.Frontiers in public health · 2021Review
- Transhepatic echocardiography: a novel approach for imaging in left ventricle assist device patients with difficult acoustic windows.European heart journal. Cardiovascular Imaging · 2020Article
- Vasoplegia following heart transplantation and left ventricular assist device explant is not associated with inferior outcomes.Journal of thoracic disease · 2020Article
- Pediatric Ventricular Assist Device Support in the Netherlands.World journal for pediatric & congenital heart surgery · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundConveying the complex trade-offs of continuous-flow left ventricular assist devices is challenging and made more difficult by absence of an evidence summary for the full range of possible outcomes. We aimed to summarize the current evidence on outcomes of continuous-flow left ventricular assist devices. METHODS AND
resultsPubMed and Cochrane Library were searched from January 2007 to December 2013, supplemented with manual review. Three reviewers independently assessed each study for saliency on patient-centered outcomes. Data were summarized in tabular form. Overall study characteristics encouraged inclusion of all indications (destination therapy and bridge to transplant) and prevented meta-analysis. The electronic search identified 465 abstracts, of which 50 met inclusion criteria; manual review added 2 articles in press. The articles included 10 industry-funded trials and registries, 10 multicenter reports, and the remainder single-center observational experiences. Estimated actuarial survival after continuous-flow left ventricular assist devices ranged from 56% to 87% at 1 year, 43% to 84% at 2 years, and 47% at 4 years. Improvements in functional class and quality of life were reported, but missing data complicated interpretation. Adverse events were experienced by the majority of patients, but estimates for bleeding, stroke, infection, right heart failure, arrhythmias, and rehospitalizations varied greatly.
conclusionsThe totality of data for continuous-flow left ventricular assist devices show consistent improvements in survival and quality of life counterbalanced by a range of common complications. Although this summary should provide a practical resource for healthcare provider-led discussions with patients, it highlights the critical need for high-quality patient-centered data collected with standard definitions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.