Trial reportAmerican journal of physiology. Endocrinology and metabolism2014
Effects of weight gain induced by controlled overfeeding on physical activity.
Trial report in American journal of physiology. Endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical activity, energy expenditure and sedentary parameters in overfeeding studies - a systematic review.BMC public health · 2018Pooled it
- Changes in 24-h energy expenditure, substrate oxidation, and body composition following resistance exercise and a high protein diet via whey protein supplementation in healthy older men.Physiological reports · 2022Trial
- Effect of Overeating Dietary Protein at Different Levels on Circulating Lipids and Liver Lipid: The PROOF Study.Nutrients · 2020Trial
- No evidence for metabolic adaptation in thermic effect of food by dietary protein.Obesity (Silver Spring, Md.) · 2016Trial
- A high protein diet (3.4 g/kg/d) combined with a heavy resistance training program improves body composition in healthy trained men and women--a follow-up investigation.Journal of the International Society of Sports Nutrition · 2015Trial
- Physiological protection against weight gain: evidence from overfeeding studies and future directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models.European journal of clinical nutrition · 2022Review
- The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.The American journal of clinical nutrition · 2021Article
- Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance.Contemporary clinical trials communications · 2020Article
- In the Footsteps of Wilbur Olin Atwater: The Atwater Lecture for 2019.Advances in nutrition (Bethesda, Md.) · 2020Article
- Metabolic response to fasting predicts weight gain during low-protein overfeeding in lean men: further evidence for spendthrift and thrifty metabolic phenotypes.The American journal of clinical nutrition · 2019Article
- Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.Nature communications · 2018Article
- Plasma Amino Acids During 8 Weeks of Overfeeding: Relation to Diet Body Composition and Fat Cell Size in the PROOF Study.Obesity (Silver Spring, Md.) · 2018Article
- Altered Feeding Behaviors and Adiposity Precede Observable Weight Gain in Young Rats Submitted to a Short-Term High-Fat Diet.Journal of nutrition and metabolism · 2018Article
- What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications?International journal of obesity (2005) · 2017Review
- Changes in Energy Expenditure with Weight Gain and Weight Loss in Humans.Current obesity reports · 2016Review
- Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity?Frontiers in human neuroscience · 2016Review
- Reciprocal Compensation to Changes in Dietary Intake and Energy Expenditure within the Concept of Energy Balance.Advances in nutrition (Bethesda, Md.) · 2015Review
- Prospective relationships between body weight and physical activity: an observational analysis from the NAVIGATOR study.BMJ open · 2015Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
It is unclear whether physical activity changes following long-term overfeeding and in response to different dietary protein intakes. Twenty-five (16 males, 9 females) healthy adults (18-35 yr) with BMI ranging from 19 to 30 kg/m(2) enrolled in this inpatient study. In a parallel group design, participants were fed 140% of energy needs, with 5, 15, or 25% of energy from protein, for 56 days. Participants wore an RT3 accelerometer for at least 59 days throughout baseline and during overfeeding and completed 24-h whole room metabolic chamber assessments at baseline and on days 1, 14, and 56 of overfeeding and on day 57, when the baseline energy intake was consumed, to measure percent of time active and spontaneous physical activity (SPA; kcal/day). Changes in activity were also assessed by doubly labeled water (DLW). From accelerometry, vector magnitude (VM), a weight-independent measure of activity, and activity energy expenditure (AEE) increased with weight gain during overfeeding. AEE remained increased after adjusting for changes in body composition. Activity-related energy expenditure (AREE) from DLW and percent activity and SPA in the metabolic chamber increased with overfeeding, but SPA was no longer significant after adjusting for change in body composition. Change in VM and AEE were positively correlated with weight gain; however, change in activity was not affected by protein intake. Overfeeding produces an increase in physical activity and in energy expended in physical activity after adjusting for changes in body composition, suggesting that increased activity in response to weight gain might be one mechanism to support adaptive thermogenesis.
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