ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 51 citations in OpenAlex.
- Developmental and tissue-specific expression of thyrotropin-releasing hormone signaling genes in zebrafish and its association with glycemic regulation.Biology open · 2026Article
- Toxicity Assessment of Metyltetraprole, a Novel Fungicide Inhibitor, to Embryo/Larval Zebrafish (Toxics · 2025Article
- Gluconeogenesis in the extraembryonic yolk syncytial layer of the zebrafish embryo.PNAS nexus · 2024Article
- Physiological functions of glucose transporter-2: From cell physiology to links with diabetes mellitus.Heliyon · 2024Review
- Mouse Memory CD8 T Cell Subsets Defined by Tissue-Resident Memory Integrin Expression Exhibit Distinct Metabolic Profiles.ImmunoHorizons · 2023Article
- Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish.BMC biology · 2023Article
- Pax4-Ghrelin mediates the conversion of pancreatic ε-cells to β-cells after extreme β-cell loss in zebrafish.Development (Cambridge, England) · 2023Article
- Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish.Scientific reports · 2022Article
- Systemic approaches using single cell transcriptome reveal that C/EBPγ regulates autophagy under amino acid starved condition.Nucleic acids research · 2022Article
- Effects of glucose ingestion at different frequencies on glycogen recovery in mice during the early hours post exercise.Journal of the International Society of Sports Nutrition · 2021Article
- Effects of post-exercise glucose ingestion at different solution temperatures on glycogen repletion in mice.Physiological reports · 2021Article
- A Great Catch for Investigating Inborn Errors of Metabolism-Insights Obtained from Zebrafish.Biomolecules · 2020Review
- Glucose transporters in brain in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Glucosamine Enhancement of BDNF Expression and Animal Cognitive Function.Molecules (Basel, Switzerland) · 2020Article
- Effects of streptozotocin on pancreatic islet β-cell apoptosis and glucose metabolism in zebrafish larvae.Fish physiology and biochemistry · 2020Article
- SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism.Angewandte Chemie (International ed. in English) · 2019Article
- Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish.Frontiers in cell and developmental biology · 2019Article
- The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRSMolecular neurobiology · 2019Article
- Transcript Analysis of Zebrafish GLUT3 Genes,Frontiers in molecular neuroscience · 2019Article
- Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish.Communications biology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose transporter 2 (GLUT2; gene name SLC2A2) has a key role in the regulation of glucose dynamics in organs central to metabolism. Although GLUT2 has been studied in the context of its participation in peripheral and central glucose sensing, its role in the brain is not well understood. To decipher the role of GLUT2 in brain development, we knocked down slc2a2 (glut2), the functional ortholog of human GLUT2, in zebrafish. Abrogation of glut2 led to defective brain organogenesis, reduced glucose uptake and increased programmed cell death in the brain. Coinciding with the observed localization of glut2 expression in the zebrafish hindbrain, glut2 deficiency affected the development of neural progenitor cells expressing the proneural genes atoh1b and ptf1a but not those expressing neurod. Specificity of the morphant phenotype was demonstrated by the restoration of brain organogenesis, whole-embryo glucose uptake, brain apoptosis, and expression of proneural markers in rescue experiments. These results indicate that glut2 has an essential role during brain development by facilitating the uptake and availability of glucose and support the involvement of glut2 in brain glucose sensing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.