Evidence map›Paper›PMID 25293823›Full record

ArticleGastrointestinal endoscopy2015

Performance characteristics of EUS for locoregional evaluation of ampullary lesions.

Wiriyaporn Ridtitid, Suzette E Schmidt, Mohammad A Al-Haddad, Julia LeBlanc, John M DeWitt, Lee McHenry, Evan L Fogel, James L Watkins, Glen A Lehman, Stuart Sherman and 1 more

Abstract readComparative Study
In one paragraph

Article in Gastrointestinal endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Clinical outcomes: endoscopic resection of duodenal ampullary lesions.Translational gastroenterology and hepatology · 2023
    Article
  6. Surgical ampullectomy: A comprehensive review.World journal of gastrointestinal surgery · 2021
    Review
  7. Review
  8. Review
  9. Article
  10. The Long-Term Outcomes of Endoscopic Papillectomy and Management of Cases of Incomplete Resection: A Single-Center Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Article
  11. [Characteristics of benign and malignant lesions of ampullary polyps and the accuracy of forceps biopsy].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. EUS and ampullary adenoma: Why? When?Endoscopy international open · 2016
    Article
  18. Review
  19. Approach to the endoscopic resection of duodenal lesions.World journal of gastroenterology · 2016
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Wiriyaporn RidtitidIndiana University School of Medicine, Indianapolis, Indiana, USA; Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Suzette E SchmidtIndiana University School of Medicine, Indianapolis, Indiana, USA.
Mohammad A Al-HaddadIndiana University School of Medicine, Indianapolis, Indiana, USA.
Julia LeBlancIndiana University School of Medicine, Indianapolis, Indiana, USA.
John M DeWittIndiana University School of Medicine, Indianapolis, Indiana, USA.
Lee McHenryIndiana University School of Medicine, Indianapolis, Indiana, USA.
Evan L FogelIndiana University School of Medicine, Indianapolis, Indiana, USA.
James L WatkinsIndiana University School of Medicine, Indianapolis, Indiana, USA.
Glen A LehmanIndiana University School of Medicine, Indianapolis, Indiana, USA.
Stuart ShermanIndiana University School of Medicine, Indianapolis, Indiana, USA.
Gregory A CotéMedical University of South Carolina, Charleston, South Carolina, USA.

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Optimizing the role of ERCP in evaluating indeterminate bile duct stricturesK23DK095148 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI COTE, GREGORY A · 2012 to 2016
$855k
NCATS NIH HHS UL1 TR001108NIDDK NIH HHS K23 DK095148
6 · The paper itself

Abstract

backgroundThe accuracy of EUS in the locoregional assessment of ampullary lesions is unclear.

objectivesTo compare EUS with ERCP and surgical pathology for the evaluation of intraductal extension and local staging of ampullary lesions.

designRetrospective cohort study.

settingTertiary-care referral center. PATIENTS: All patients who underwent EUS primarily for the evaluation of an ampullary lesion between 1998 and 2012.

interventionEUS. MAIN OUTCOME MEASUREMENTS: Comparison of EUS sensitivity/specificity for intraductal and local extension with ERCP and surgical pathology by using the area under the receiver-operating characteristic (AUROC) curves and outcomes of the subgroup referred for endoscopic papillectomy.

resultsWe identified 119 patients who underwent EUS for an ampullary lesion, of whom 99 (83%) had an adenoma or adenocarcinoma. Compared with ERCP (n = 90), the sensitivity/specificity of EUS for any intraductal extension was 56%/97% (AUROC = 0.77; 95% confidence interval [CI], 0.64-0.89). However, when using surgical pathology as the reference (n = 102), the sensitivity/specificity of EUS (80%/93%; AUROC = 0.87; 95% CI, 0.76-0.97) and ERCP (83%/93%; AUROC = 0.88; 95% CI, 0.77-0.99) were comparable. The overall accuracy of EUS for local staging was 90%. Of 58 patients referred for endoscopic papillectomy, complete resection was achieved in 53 (91%); in those having intraductal extension by EUS or ERCP, complete resection was achieved in 4 of 5 (80%) and 4 of 7 (57%), respectively. LIMITATION: Retrospective design.

conclusionsEUS and ERCP perform similarly in evaluating intraductal extension of ampullary adenomas. Additionally, EUS is accurate in T-staging ampullary adenocarcinomas. Future prospective studies should evaluate whether EUS can identify characteristics of ampullary lesions that appropriately direct patients to endoscopic or surgical resection.

Indexed as

Ampulla of VaterEndosonographyAdenocarcinomaAdenomaAgedAged, 80 and overCholangiopancreatography, Endoscopic RetrogradeCommon Bile Duct NeoplasmsFemaleHumansMaleMiddle AgedNeoplasm StagingPredictive Value of TestsRetrospective StudiesROC Curve

Identifiers

PMID25293823
PMCPMC4322681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.