ArticleEuropean journal of human genetics : EJHG2015
A genetic risk score for hypertension associates with the risk of ischemic stroke in a Swedish case-control study.
Article in European journal of human genetics : EJHG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 33 citations in OpenAlex.
- Causal assessment of the relationship between diet, lifestyle, and stroke: A two-sample Mendelian randomization study.Medicine · 2025Article
- Using Machine Learning to Evaluate the Value of Genetic Liabilities in the Classification of Hypertension within the UK Biobank.Journal of clinical medicine · 2024Article
- Stroke and Etiopathogenesis: What Is Known?Genes · 2022Review
- Review
- A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Article
- Maternal Hypertension-Related Genotypes and Congenital Heart Defects.American journal of hypertension · 2021Article
- Who will benefit from bariatric surgery for diabetes? A protocol for an observational cohort study.BMJ open · 2021Article
- Article
- Identification of additional EHMT2 variant associated with the risk of chronic hepatitis B by GWAS follow-up study.Genes and immunity · 2019Article
- Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.BMJ (Clinical research ed.) · 2018Article
- Risk for hypertension crosses generations in the community: a multi-generational cohort study.European heart journal · 2017Article
- Heritability and risks associated with early onset hypertension: multigenerational, prospective analysis in the Framingham Heart Study.BMJ (Clinical research ed.) · 2017Article
- Epidemiology of cardiovascular disease: recent novel outlooks on risk factors and clinical approaches.Expert review of cardiovascular therapy · 2016Review
- Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia.American journal of hypertension · 2016Article
- Article
- The Role of Genetic Risk Score in Predicting the Risk of Hypertension in the Korean population: Korean Genome and Epidemiology Study.PloS one · 2015Article
- Current Applications of Genetic Risk Scores to Cardiovascular Outcomes and Subclinical Phenotypes.Current epidemiology reportsReview
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Authors and funding
11 authors at 2 institutions in 1 country.
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Abstract
Genetic risk scores (GRS), summing up the total effect of several single-nucleotide polymorphisms (SNPs) in genes associated with either coronary risk or cardiovascular risk factors, have been tested for association with ischemic stroke with conflicting results. Recently an association was found between a GRS based on 29 SNPs discovered by genome-wide association studies and hypertension. The aim of our study was to investigate the possible association of the same GRS with ischemic stroke on top of other 'traditional risk factors', also testing its potential improvement in indices of discrimination and reclassification, in a Swedish case-control study. Twenty-nine SNPs were genotyped in 3677 stroke cases and 2415 controls included in the Lund Stroke Register (LSR), the Malmö Diet and Cancer (MDC) study and the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). The analysis was conducted in the combined sample, and separately for the three studies. After adjustment for hypertension, diabetes mellitus and smoking habits, the GRS was associated with ischemic stroke in the combined sample (OR (95% CI) 1.086 (1.029-1.147) per SD increase in the GRS P=0.003) with similar trends in all three samples: LSR (1.050 (0.967-1.140); P=0.25), MDC (1.168 (1.060-1.288); P=0.002) and SAHLSIS (1.124 (0.997-1.267); P=0.055). Measures of risk discrimination and reclassification improved marginally using the GRS. A blood pressure GRS is independently associated with ischemic stroke risk in three Swedish case-control studies, however, the effect size is low and adds marginally to prediction of stroke on top of traditional risk factors including hypertension.
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