ArticleBMJ case reports2014
Emotionally-intense situations can result in rhabdomyolysis in McArdle disease.
Article in BMJ case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Pregnancy in Patients With McArdle's Disease.Cureus · 2025Review
- Rhabdomyolysis in McArdle disease caused by scuba diving.BMJ case reports · 2023Article
- McArdle disease and pregnancy: A case report and scoping review of pregnancy outcomes.Obstetric medicine · 2022Article
- How to do it: investigate exertional rhabdomyolysis (or not).Practical neurology · 2019Review
- Non-traumatic and non-drug-induced rhabdomyolysis.Archives of medical sciences. Atherosclerotic diseases · 2019Article
- McArdle Disease Misdiagnosed as Meningitis.The American journal of case reports · 2016Article
- Rhabdomyolysis: a genetic perspective.Orphanet journal of rare diseases · 2015Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the majority of patients with McArdle disease reporting symptoms including fatigue, cramps and episodes of myoglobinuria from early childhood, diagnosis is often delayed by several decades. Additionally, many individuals with rhabdomyolysis remain undiagnosed. The occurrence of symptoms during exercise, particularly isometric muscle contraction such as heavy lifting, is well known in McArdle disease. However, isometric muscle contraction that occurs with emotion is not recognised as exercise and may be missed as a trigger for rhabdomyolysis, potentially leading to a delay in diagnosis. Three patients are presented here, all with symptoms from childhood including episodes of rhabdomyolysis induced by tense emotional situations without physical exertion; two patients reported recurrent episodes while watching rather than playing football. The remaining patient developed rhabdomyolysis during a heated argument. These patients' histories emphasise the risk from sustained isometric muscle contraction that occurs in emotive situations for patients with McArdle disease.
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