Evidence map›Paper›PMID 25293442›Full record

Trial reportDiabetes & metabolic syndrome

Effects of a community-based weight loss intervention on adipose tissue circulating factors.

Gary D Miller, Scott Isom, Timothy M Morgan, Mara Z Vitolins, Caroline Blackwell, K Bridget Brosnihan, Debra I Diz, Jeff Katula, David Goff

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00631345 (Translating Research Into the Prevention of Diabetes Mellitus), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00631345 nacompletednot on this map

Translating Research Into the Prevention of Diabetes Mellitus (TRIP DM)

TypeinterventionalSponsorWake Forest University Health SciencesRan2007 to 2015Enrolled301ConditionsPrediabetes, ObesityArmsGroup-Based Lifestyle Intervention (Phases 1 and 2), Individual Education Program (All Phases), Self-Directed Maintenance (Phase 3), Extended Group Maintenance (Phase 3)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Trial
  5. Trial
  6. Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gary D MillerDepartment of Health and Exercise Science, and Translational Science Center, Wake Forest University, United States. Electronic address: millergd@wfu.edu.
Scott IsomDepartment of Public Health Sciences, Wake Forest School of Medicine, United States.
Timothy M MorganDepartment of Public Health Sciences, Wake Forest School of Medicine, United States.
Mara Z VitolinsDepartment of Public Health Sciences, Wake Forest School of Medicine, United States.
Caroline BlackwellDepartment of Public Health Sciences, Wake Forest School of Medicine, United States.
K Bridget BrosnihanDepartment of General Surgery and The Hypertension and Vascular Research Center, Wake Forest School of Medicine, United States.
Debra I DizDepartment of General Surgery and The Hypertension and Vascular Research Center, Wake Forest School of Medicine, United States.
Jeff KatulaDepartment of Health and Exercise Science, and Translational Science Center, Wake Forest University, United States.
David GoffColorado School of Public Health, United States.

Funding

Translating Research into Prevention of Diabetes (TRIP Diabetes)R18DK069901 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KATULA, JEFFREY A., VITOLINS, MARA Z · 2006 to 2014
$6.1M
NIDDK NIH HHS R18 DK069901
6 · The paper itself

Abstract

aimsObesity is associated with metabolic dysfunctions, which may be mediated by changes in adipose tissue signaling factors. These molecules are denoted as Adipose Tissue Generated Mediators of CardioVascular Risk (ATGMCVR) here, and include leptin, adiponectin, C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNFα), and plasminogen activator inhibitor 1 (PAI-1). This study examined the effect of a weight loss program on ATGMCVR in obese adults with prediabetes. MATERIALS AND

methodsSubjects were randomized to usual care (UC; n=15) or lifestyle weight loss groups (LWL; n=15). LWL was a community-based weight loss intervention to promote physical activity and healthy eating. ATGMCVR at 1-year were compared between groups by analysis of covariance; baseline value of the mediator was the covariate. Baseline means for ATGMCVR were compared between those with (n=21) and without (n=9) metabolic syndrome (MetS).

resultsAt baseline, subjects were 58±9 (SD) years, 70% female, with a BMI of 34±4kg/m(2). One-year weight loss (%) was 7.8±6.0% for LWL and 1.7±4.5% for UC. Group differences at 1-year were noted (adjusted means [95%CI] for UC and LWL, respectively) for adiponectin (8526.3 [7397.7, 9827]; 10,870.9 [9432.0, 12,529.3]ng/ml; p=0.02), leptin (30.4 [26.1, 35.4]; 23.7 [20.3, 27.5]ng/ml; p=0.02), IL-6 (0.4 [0.3, 0.5]; 0.2 [0.1, 0.2] pg/ml; p=0.001), and PAI-1 (50 [42.7, 58.7]; 36.2 [30.8, 42.4]pg/ml; p=0.01). No differences in baseline ATGMCVR were seen between subjects with and without MetS.

conclusionThese findings suggest ATGMCVR can be improved with weight loss; larger studies are needed to determine if improvements in metabolic dysfunction are related to changes in ATGMCVR.

Indexed as

Community Health CentersWeight Reduction ProgramsAdiponectinAdipose TissueBiomarkersBody Mass IndexCardiovascular DiseasesC-Reactive ProteinDiet, ReducingExerciseFemaleHumansInflammationInsulin ResistanceInterleukin-6LeptinAdiponectinBiomarkersC-Reactive ProteinInterleukin-6LeptinPlasminogen Activator Inhibitor 1SERPINE1 protein, humanTumor Necrosis Factor-alphaAdipose tissueDiabetesMetabolic syndromeObesityPrediabetesWeight loss

Identifiers

PMID25293442
PMCPMC4254144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.