ArticleEuropean journal of clinical nutrition2015
High sodium intake is associated with important risk factors in a large cohort of chronic kidney disease patients.
Article in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Dietary Sodium Intake and Health Indicators: A Systematic Review of Published Literature between January 2015 and December 2019.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people.Nature reviews. Nephrology · 2019Guideline
- The Science of Salt: A Regularly Updated Systematic Review of Salt and Health Outcomes (August to November 2015).Journal of clinical hypertension (Greenwich, Conn.) · 2016Pooled it
- The Science of Salt: A Regularly Updated Systematic Review of Salt and Health Outcomes (June and July 2015).Journal of clinical hypertension (Greenwich, Conn.) · 2016Pooled it
- Chronobiology of meal timing in early-stage hypertension: a controlled feeding pilot study investigating the effects on renal and vascular function.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- An Evaluation of Alternative Technology-Supported Counseling Approaches to Promote Multiple Lifestyle Behavior Changes in Patients With Type 2 Diabetes and Chronic Kidney Disease.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2023Trial
- Opposing effects of sodium intake on uric acid and blood pressure and their causal implication.Journal of the American Society of Hypertension : JASH · 2016Trial
- QuantitativeMagma (New York, N.Y.) · 2024Article
- Risk Factors of Chronic Kidney Disease Progression: Between Old and New Concepts.Journal of clinical medicine · 2024Review
- Trends and future predictions of chronic kidney disease due to diabetes mellitus type 2 attributable to dietary risks: insights based on GBD 2021 data.Frontiers in nutrition · 2024Article
- Efficacy of comprehensive group-based education in lowering body weight, uric acid levels, and diuretic use in patients with chronic kidney disease: a retrospective study.BMC nephrology · 2023Article
- Yellow Pea Pasta Enhances the Saltiness and Suppression of Postprandial Blood Glucose Elevation.Nutrients · 2023Article
- Sodium-glucose co-transporter 2 inhibitor therapy: use in chronic kidney disease and adjunctive sodium restriction.Internal medicine journal · 2022Review
- Is socio-demographic status, body mass index, and consumption of food away from home associated with high sodium intake among adults in Malaysia?: findings from the Malaysian Community Salt Survey (MyCoSS).Journal of health, population, and nutrition · 2021Article
- The Correlation amongst Salty Taste Preference and Overactive Bladder Symptoms in Female Individuals.International journal of environmental research and public health · 2021Article
- Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease: the Fukuoka kidney disease registry study.Clinical and experimental nephrology · 2021Article
- Association between sodium intake and lower urinary tract symptoms: does less sodium intake have a favorable effect or not?Translational andrology and urology · 2020Article
- High-Salt Loading Downregulates Nrf2 Expression in a Sodium-Dependent Manner in Renal Collecting Duct Cells.Frontiers in physiology · 2019Article
- Reduced Renal Mass, Salt-Sensitive Hypertension Is Resistant to Renal Denervation.Frontiers in physiology · 2018Article
- Dietary sources of energy and nutrient intake among children and adolescents with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesAn increased risk of mortality and cardiovascular disease (CVD) is observed in people with chronic kidney disease (CKD) even in early stages. Dietary sodium intake has been associated with important CVD and CKD progression risk factors such as hypertension and proteinuria in this population. We aimed to investigate the relationship between sodium intake and CVD or CKD progression risk factors in a large cohort of patients with CKD stage 3 recruited from primary care. SUBJECTS/
methodsA total of 1733 patients with previous estimated glomerular filtration rate (eGFR) of 30-59 ml/min/1.73m(2), with a mean age 72.9±9.0 years, were recruited from 32 general practices in primary care in England. Medical history was obtained and participants underwent clinical assessment, urine and serum biochemistry testing. Sodium intake was estimated from three early-morning urine specimens using an equation validated for this study population.
resultsSixty percent of participants who had estimated sodium intake above recommendation (>100 mmol/day or 6 g salt/day) also had higher diastolic blood pressure, mean arterial pressure (MAP), urinary albumin-to-creatinine ratio, high-sensitive C-reactive protein and uric acid and used a greater number of anti-hypertensive drugs. In multivariable regression analysis, excessive sodium intake was an independent predictor of MAP (B=1.57, 95% confidence interval (CI) 0.41-2.72; P=0.008) and albuminuria (B=1.35, 95% CI 1.02-1.79; P=0.03).
conclusionsHigh sodium intake was associated with CVD and CKD progression risk factors in patients with predominantly early stages of CKD followed up in primary care. This suggests that dietary sodium intake could afffect CVD risk even in early or mild CKD. Intervention studies are warranted to investigate the potential benefit of dietary advice to reduce sodium intake in this population.
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