ReviewParasite (Paris, France)2014
Immune modulation by helminth parasites of ruminants: implications for vaccine development and host immune competence.
Review in Parasite (Paris, France), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Helminths of veterinary and zoonotic importance in Nigerian ruminants: a 46-year meta-analysis (1970-2016) of their prevalence and distribution.Infectious diseases of poverty · 2018Pooled it
- Infection byThe Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- Life Stage-Specific Burdens and Impacts of Gastrointestinal Nematodes in Beef Cattle in the United States: A Review of Diagnostics, Impacts on Productivity, and Immune Response.Veterinary sciences · 2026Review
- Helminthic Infections and Vaccine Efficacy in Cattle: Implications for Disease Control and Sustainable Livestock Production.Veterinary sciences · 2025Review
- Modulation of the Immune Response by Nematode Derived Molecules.International journal of molecular sciences · 2025Review
- A Modified Variant ofVaccines · 2025Article
- Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19.Vaccines · 2025Article
- Trypanosoma vivax elicits both Th1 and Th2 immunological responses in experimentally infected cattle.PloS one · 2025Article
- Structural and functional analyses of nematode-derived antimicrobial peptides support the occurrence of direct mechanisms of worm-microbiota interactions.Computational and structural biotechnology journal · 2024Article
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- Field testing of recombinant subunit vaccines againstFrontiers in parasitology · 2024Article
- Helminth Control Practices in Sheep and Cattle in Urban and Peri-Urban Areas of Adea District, Central Ethiopia.Veterinary medicine (Auckland, N.Z.) · 2024Article
- Roles of Cysteine Proteases in Biology and Pathogenesis of Parasites.Microorganisms · 2023Article
- The Economic Impact of Parasitism from Nematodes, Trematodes and Ticks on Beef Cattle Production.Animals : an open access journal from MDPI · 2023Review
- The Immune Response to Nematode Infection.International journal of molecular sciences · 2023Review
- Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases?Frontiers in immunology · 2023Review
- Prevalence of intestinal parasites in animal hosts and potential implications to animal and human health in Edo, Nigeria.Journal of veterinary science · 2023Article
- Liver Proteome Alterations in Red Deer (Pathogens (Basel, Switzerland) · 2022Article
- Communication is key: Innate immune cells regulate host protection to helminths.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasitic helminths reside in immunologically-exposed extracellular locations within their hosts, yet they are capable of surviving for extended periods. To enable this survival, these parasites have developed complex and multifaceted mechanisms to subvert or suppress host immunity. This review summarises current knowledge of immune modulation by helminth parasites of ruminants and the parasite-derived molecules involved in driving this modulation. Such immunomodulatory molecules have considerable promise as vaccine targets, as neutralisation of their function is predicted to enhance anti-parasite immunity and, as such, current knowledge in this area is presented herein. Furthermore, we summarise current evidence that, as well as affecting parasite-specific immunity, immune modulation by these parasites may also affect the ability of ruminant hosts to control concurrent diseases or mount effective responses to vaccination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.