Evidence map›Paper›PMID 25292435›Full record

ReviewAnnual review of pharmacology and toxicology2015

Improving postapproval drug safety surveillance: getting better information sooner.

Sean Hennessy, Brian L Strom

Abstract readReview
In one paragraph

Review in Annual review of pharmacology and toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Predicting Drug Blood-Brain Barrier Penetration with Adverse Event Report Embeddings.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sean HennessyCenter for Pharmacoepidemiology Research and Training.
Brian L Strom

Funding

Clinical Importance of Drug-Drug InteractionsR01AG025152 · NIA · UNIVERSITY OF PENNSYLVANIA · PI HENNESSY, SEAN, LI, LANG · 2006 to 2021
$8.1M
Immunology and Outcomes after HAART in HIV/TB CoinfectionR01AI080337 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BISSON, GREGORY P. · 2009 to 2013
$3.5M
Enabling Medical Research Growth in Emergency MedicineK12HL109009 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KIMMEL, STEPHEN E. · 2011 to 2015
$3.4M
Pharmacogenetics and HIV treatment outcomesR01MH080701 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GROSS, ROBERT · 2009 to 2013
$2.6M
Drug-Drug Interactions Involving Antidiabetic AgentsR01DK102694 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HENNESSY, SEAN, LI, LANG · 2014 to 2017
$2.4M
Institutional Clinical and Translational Science AwardTL1RR024133 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$1.3M
Chronic disease clinical epidemiology training in guatemala and peruD43TW008317 · FIC · UNIVERSITY OF PENNSYLVANIA · PI BRANAS, CHARLES C. · 2010 to 2014
$1.1M
Injury and Trauma Research Training for GuatemalaD43TW008972 · FIC · UNIVERSITY OF PENNSYLVANIA · PI RICHMOND, THERESE S. · 2011 to 2015
$1.0M
AHRQ HHS R01 HS018372FIC NIH HHS D43 TW008317FIC NIH HHS D43 TW008972NCRR NIH HHS TL1 RR024133NHLBI NIH HHS K12 HL109009NIAID NIH HHS R01 AI080337NIA NIH HHS R01 AG025152NIDDK NIH HHS R01 DK102694NIMH NIH HHS R01 MH080701
6 · The paper itself

Abstract

Adverse drug events (ADEs) are an important public health concern, accounting for 5% of all hospital admissions and two-thirds of all complications occurring shortly after hospital discharge. There are often long delays between when a drug is approved and when serious ADEs are identified. Recent and ongoing advances in drug safety surveillance include the establishment of government-sponsored networks of population databases, the use of data mining approaches, and the formal integration of diverse sources of drug safety information. These advances promise to reduce delays in identifying drug-related risks and in providing reassurance about the absence of such risks.

Indexed as

Adverse Drug Reaction Reporting SystemsAccess to InformationData MiningDrug-Related Side Effects and Adverse ReactionsEvidence-Based MedicineHumansInformation DisseminationPatient SafetyPrescription DrugsProduct Surveillance, PostmarketingRisk AssessmentRisk FactorsPrescription Drugsadverse drug reaction reporting systemspharmacoepidemiologypostmarketingprecision medicineprediction in pharmacologyproduct surveillance

Identifiers

PMID25292435
PMCPMC4677571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.