Evidence map›Paper›PMID 25292357›Full record

ReviewAnnual review of genetics2014

Messenger RNA degradation in bacterial cells.

Monica P Hui, Patricia L Foley, Joel G Belasco

Abstract readReview
In one paragraph

Review in Annual review of genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed.

  1. Structural and biophysical insights into the unique RNase YicC.bioRxiv : the preprint server for biology · 2026
    Article
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  5. Developing the protein quality control system inSynthetic and systems biotechnology · 2026
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  20. Review

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Monica P HuiKimmel Center for Biology and Medicine at the Skirball Institute and Department of Microbiology, New York University School of Medicine, New York, NY 10016; email: joel.belasco@med.nyu.edu.
Patricia L Foley
Joel G Belasco

Funding

Prokaryotic RNA Metabolism - Resubmission - 1R01GM035769 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BELASCO, JOEL G · 1986 to 2021
$7.1M
Effectors and regulators of end-dependent mRNA degradation in bacteriaF32GM101962 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HUI, MONICA PING-TING · 2012 to 2014
$156k
NIGMS NIH HHS F32 GM101962NIGMS NIH HHS F32GM101962NIGMS NIH HHS R01 GM035769NIGMS NIH HHS R01GM035769
6 · The paper itself

Abstract

mRNA degradation is an important mechanism for controlling gene expression in bacterial cells. This process involves the orderly action of a battery of cellular endonucleases and exonucleases, some universal and others present only in certain species. These ribonucleases function with the assistance of ancillary enzymes that covalently modify the 5' or 3' end of RNA or unwind base-paired regions. Triggered by initiating events at either the 5' terminus or an internal site, mRNA decay occurs at diverse rates that are transcript specific and governed by RNA sequence and structure, translating ribosomes, and bound sRNAs or proteins. In response to environmental cues, bacteria are able to orchestrate widespread changes in mRNA lifetimes by modulating the concentration or specific activity of cellular ribonucleases or by unmasking the mRNA-degrading activity of cellular toxins.

Indexed as

EndoribonucleasesEscherichia coliGene Expression Regulation, BacterialMultienzyme ComplexesPhylogenyPolyribonucleotide NucleotidyltransferaseRibonucleasesRibosomesRNA HelicasesRNA, MessengerRNA StabilitydegradosomeEndoribonucleasesMultienzyme ComplexesPolyribonucleotide NucleotidyltransferaseRibonucleasesRNA HelicasesRNA, Messengergene regulationmRNA stabilityribonucleasesRNAtranslation

Identifiers

PMID25292357
PMCPMC4431577

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.