ArticleNeuroradiology2015
Childhood encephalitis: relationship between diffusion abnormalities and clinical outcome.
Article in Neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Disrupted age-related glymphatic patterns in children with deep gray matter hypoxic-ischemic encephalopathy: a diffusion tensor imaging analysis along the perivascular space study.Neuroradiology · 2026Article
- MRI of fatal course of acute hemorrhagic leukoencephalitis in a child with SARS-CoV-2 omicron BA 2.0 infection.Neuroradiology · 2023Article
- [Clinical features of children with coronavirus disease 2019 complicated by acute encephalitis and related research advances].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Review
- Spectrum of neuroimaging mimics in children with COVID-19 infection.Biomedical journal · 2022Review
- Epidemiology and Etiology of Severe Childhood Encephalitis in The Netherlands.The Pediatric infectious disease journal · 2020Article
- Arterial spin-labeling perfusion imaging of childhood encephalitis: correlation with seizure and clinical outcome.Neuroradiology · 2018Article
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8 authors.
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Abstract
introductionThe impact of restricted diffusion on clinical outcome has not been well studied in childhood encephalitis. We hypothesized that the patients with lesions with restricted diffusion (LRD) would have worse clinical outcome.
methodsWe reviewed the MR studies of 83 children with encephalitis for LRD. An MRI scoring system (0-12) based on fluid-attenuated inversion recovery (FLAIR) imaging was created to evaluate the extent of imaging abnormality. Clinical outcome was graded by using Glasgow outcome scale (GOS) (1-5) in 1st and 12th month: 1 for death and five for full recovery. With respect to diffusion, the correlation between imaging score and GOS was assessed. Logistic regression analysis was used to explore the impact of diffusion and imaging score on clinical outcome. The patients were divided into three subgroups regarding imaging score: I, 0-4; II, 5-8; and III, 9-12.
resultsLRD was found in 28 patients. Negative significant correlation was found between imaging score and GOS in the group with LRD in both 1st month (R = -0.67, P < 0.001) and 12th month (R = -0.56, P = 0.001). Multivariate logistic regression showed that LRD (P < 0.001) and age (P = 0.026) were significant independent risk factors for unfavorable outcome in 1st month, and both LRD (P = 0.001) and imaging score (P = 0.043) were significant risk factors for unfavorable outcome in 12th month.
conclusionsPatients with LRD have a worse clinical outcome than those without LRD. In patients with LRD, those with a greater extent of abnormality have a poorer outcome.
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