Evidence map›Paper›PMID 25292303›Full record

ArticleEnvironmental science and pollution research international2016

Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France.

Laetitia Minguez, Julie Pedelucq, Emilie Farcy, Céline Ballandonne, Hélène Budzinski, Marie-Pierre Halm-Lemeille

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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  7. Remediation strategies of antiretroviral drugs in the aquatic environment: current trend and future perspectives.Water science and technology : a journal of the International Association on Water Pollution Research · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
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  15. Article
  16. Effects of an Endocrine Disruptor Triclosan onAnimals : an open access journal from MDPI · 2023
    Article
  17. Review
  18. Household Pharmaceutical Waste Disposal as a Global Problem-A Review.International journal of environmental research and public health · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laetitia MinguezUMR BOREA (Biologie des ORganismes et Ecosystèmes Aquatiques), CNRS-7208/MNHN/UPMC/IRD-207/UCBN, Esplanade de la Paix, 14032, Caen Cedex, France. laetitia-minguez@hotmail.fr.
Julie PedelucqEPOC (Environnements et Paléoenvironnements Océaniques et Continentaux), UMR 5805 CNRS, Laboratoire de Physico- et Toxico-Chimie de l'Environnement (LPTC), 351 crs de la Libération, 33405, Talence, France.
Emilie FarcyUMR BOREA (Biologie des ORganismes et Ecosystèmes Aquatiques), CNRS-7208/MNHN/UPMC/IRD-207/UCBN, Esplanade de la Paix, 14032, Caen Cedex, France.
Céline BallandonneCERMN, UFR des Sciences Pharmaceutiques, UPRES EA4258 - FR CNRS INC3M - SF 4206 ICORE, Université de Caen Basse-Normandie, Bd Becquerel, 14032, Caen Cedex, France.
Hélène BudzinskiEPOC (Environnements et Paléoenvironnements Océaniques et Continentaux), UMR 5805 CNRS, Laboratoire de Physico- et Toxico-Chimie de l'Environnement (LPTC), 351 crs de la Libération, 33405, Talence, France.
Marie-Pierre Halm-LemeilleCERMN, UFR des Sciences Pharmaceutiques, UPRES EA4258 - FR CNRS INC3M - SF 4206 ICORE, Université de Caen Basse-Normandie, Bd Becquerel, 14032, Caen Cedex, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A risk assessment for freshwater and marine ecosystems is presented for 48 pharmaceutical compounds, belonging to 16 therapeutic classes, and prescribed in northwestern France. Ecotoxicity data were obtained on two freshwater organisms, i.e., crustacean Daphnia magna and the green algae Pseudokirchneriella subcapitata, and on two marine organisms, i.e., the crustacean Artemia salina and the diatom Skeletonema marinoi. Measured environmental concentrations (MEC), in the Orne River and sea off Merville-Franceville in the Basse-Normandie region, were compared to the predicted environmental concentrations (PEC). Predicted no-effect concentrations (PNEC) were derived from acute data for each compound. Then, a risk assessment for each compound and the mixture was performed by calculating risk quotients (RQ as PEC or MEC/PNEC ratio). Results showed that no immediate acute toxicities were expected even if some compounds displayed strong toxicities at very low concentrations. Antibiotics, antidepressants, and antifungals would deserve attention because of their high or median ecological risk suspected on marine and freshwater ecosystems. Marine ecosystems would be more sensitive to pharmaceutical residues.

Indexed as

Environmental MonitoringAnimalsChlorophytaDaphniaEcosystemFranceFresh WaterPharmaceutical PreparationsRisk AssessmentWater Pollutants, ChemicalPharmaceutical PreparationsWater Pollutants, ChemicalAquatic environmentEcotoxicityFateMECPECPharmaceuticalsRisk

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.