ArticlePflugers Archiv : European journal of physiology2015
Characterisation of rebound depolarisation in mice deep dorsal horn neurons in vitro.
Article in Pflugers Archiv : European journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- An electrophysiologist's guide to dorsal horn excitability and pain.Frontiers in cellular neuroscience · 2025Review
- Synchronous firing of dorsal horn neurons at the origin of dorsal root reflexes in naïve and paw-inflamed mice.Frontiers in cellular neuroscience · 2022Article
- Electrophysiological and Morphological Features of Rebound Depolarization Characterized Interneurons in Rat Superficial Spinal Dorsal Horn.Frontiers in cellular neuroscience · 2021Article
- Origin and classification of spontaneous discharges in mouse superficial dorsal horn neurons.Scientific reports · 2018Article
- Excitability of Rat Superficial Dorsal Horn Neurons Following a Neonatal Immune Challenge.Frontiers in neurology · 2018Article
- Genetic Tracing of CaFrontiers in molecular neuroscience · 2017Article
- Analysis of spontaneous activity of superficial dorsal horn neurons in vitro: neuropathy-induced changes.Pflugers Archiv : European journal of physiology · 2016Article
- Intrinsic excitability differs between murine hypoglossal and spinal motoneurons.Journal of neurophysiology · 2016Article
- Lidocaine Inhibits HCN Currents in Rat Spinal Substantia Gelatinosa Neurons.Anesthesia and analgesia · 2016Article
- [Rebound depolarization of substantia gelatinosa neurons and its modulatory mechanisms in rat spinal dorsal horn].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2016Article
- Amplified parabrachial nucleus activity in a rat model of trigeminal neuropathic pain.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal dorsal horn neurons constitute the first relay for pain processing and participate in the processing of other sensory, motor and autonomic information. At the cellular level, intrinsic excitability is a factor contributing to network function. In turn, excitability is set by the array of ionic conductance expressed by neurons. Here, we set out to characterise rebound depolarisation following hyperpolarisation, a feature frequently described in dorsal horn neurons but never addressed in depth. To this end, an in vitro preparation of the spinal cord from mice pups was used combined with whole-cell recordings in current and voltage clamp modes. Results show the expression of H- and/or T-type currents in a significant proportion of dorsal horn neurons. The expression of these currents determines the presence of rebound behaviour at the end of hyperpolarising pulses. T-type calcium currents were associated to high-amplitude rebounds usually involving high-frequency action potential firing. H-currents were associated to low-amplitude rebounds less prone to elicit firing or firing at lower frequencies. For a large proportion of neurons expressing both currents, the H-current constitutes a mechanism to ensure a faster response after hyperpolarisations, adjusting the latency of the rebound firing. We conclude that rebound depolarisation and firing are intrinsic factors to many dorsal horn neurons that may constitute a mechanism to integrate somatosensory information in the spinal cord, allowing for a rapid switch from inhibited-to-excited states.
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