ArticleJournal of thrombosis and haemostasis : JTH2014
Inflammation markers and incident venous thromboembolism: the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.
Article in Journal of thrombosis and haemostasis : JTH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Serum C-reactive protein increases the risk of venous thromboembolism: a prospective study and meta-analysis of published prospective evidence.European journal of epidemiology · 2017Pooled it
- A nomogram for assessing the risk of deep vein thrombosis following surgery for pilon fractures.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Article
- SevereFrontiers in medicine · 2025Article
- Article
- Review
- The association between lactate dehydrogenase to serum albumin ratio and in-hospital mortality in patients with pulmonary embolism: a retrospective analysis of the MIMIC-IV database.Frontiers in cardiovascular medicine · 2024Article
- A nomogram for predicting the risk of venous thromboembolism in patients with solid cancers.Journal of thrombosis and thrombolysis · 2023Article
- Association between inflammatory biomarkers and venous thromboembolism: a systematic review and meta-analysis.Thrombosis journal · 2023Review
- The effect of rivaroxaban on biomarkers in blood and plasma: a review of preclinical and clinical evidence.Journal of thrombosis and thrombolysis · 2023Review
- Epidemiology and prevention of venous thromboembolism.Nature reviews. Cardiology · 2023Review
- Evaluation of the relationship between monocyte to high-density lipoprotein cholesterol ratio and thrombus burden in patients with deep vein thrombosis.Revista da Associacao Medica Brasileira (1992) · 2023Article
- The benefit of hindsight: An unusual presentation of deep vein thrombosis in spinal cord injury.Turkish journal of physical medicine and rehabilitation · 2022Article
- Plasma lipopolysaccharide-binding protein is a biomarker for future venous thromboembolism: Results from discovery and validation studies.Journal of internal medicine · 2022Article
- The Interplay of Race/Ethnicity and Obesity on the Incidence of Venous Thromboembolism.American journal of preventive medicine · 2022Article
- Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism.Journal of thrombosis and haemostasis : JTH · 2022Article
- Commentary on "Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism": A new role for plasminogen activator inhibitor-1-An inhibitor of fibrinolysis predicts future venous thromboembolic events and links them to obesity.Journal of thrombosis and haemostasis : JTH · 2022Article
- Associations of Novel Lifestyle- and Whole Foods-Based Inflammation Scores with Incident Colorectal Cancer Among Women.Nutrition and cancer · 2022Article
- Applicability of the Padua scale for Chinese rheumatic in-patients with venous thromboembolism.PloS one · 2022Article
- C-reactive protein, immunothrombosis and venous thromboembolism.Frontiers in immunology · 2022Review
- Hyperlipidemia and Obesity's Role in Immune Dysregulation Underlying the Severity of COVID-19 Infection.Clinics and practice · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundInflammation biomarkers are associated with the venous thromboembolism (VTE) risk factors obesity and age; however, the relationships of inflammation with VTE risk remain controversial.
objectivesTo examine associations of four inflammation biomarkers, i.e. C-reactive protein (CRP), serum albumin, white blood cell (WBC) count, and platelet count (PLTC), with incident VTE, and to determine whether they mediate the association of age or obesity with VTE. PATIENTS/
methodsHazards models adjusted for VTE risk factors were used to calculate the prospective association of each biomarker with incident VTE in 30,239 participants of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Mediation of the associations of obesity and age with VTE were examined by bootstrapping. Over a period of 4.6 years, there were 268 incident VTE events. After adjustment for VTE risk factors, the hazard ratios (HRs) were 1.25 (95% confidence interval [CI] 1.09-1.43) per standard deviation (SD) higher log-CRP and 1.25 (95% CI 1.06-1.48) per SD lower albumin; there were no associations for WBC count or PLTC. The association of body mass index (BMI), but not age, with VTE was partially mediated by CRP and albumin. In risk factor-adjusted models, the percentage attenuations of the BMI HR for VTE after introduction of CRP or albumin into the models were 15.4% (95% CI 7.7-33.3%) and 41.0% (95% CI 12.8-79.5%), respectively.
conclusionHigher CRP levels and lower serum albumin levels were associated with increased VTE risk, and statistically mediated part of the association of BMI with VTE. These data suggest that inflammation may be a potential mechanism underlying the relationship between obesity and VTE risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.