ArticleInternational journal of occupational and environmental health2015
Exposure to polycyclic aromatic hydrocarbons (PAHs) and bladder cancer: evaluation from a gene-environment perspective in a hospital-based case-control study in the Canary Islands (Spain).
Article in International journal of occupational and environmental health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The genitourinary impacts of electronic cigarette use: a systematic review of the literature.World journal of urology · 2023Pooled it
- Cigarette smoking and risk of bladder cancer: a dose-response meta-analysis.International urology and nephrology · 2022Pooled it
- Human Biomonitoring of Environmental and Occupational Exposures by GC-MS and Gas Sensor Systems: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Public Health Effects of Polycyclic Aromatic Hydrocarbons Exposure Through Air, Water, Soil, and Food in Ghana: Possible Economic Burden.Environmental health insights · 2025Review
- Aryl hydrocarbon receptor-dependent toxicity by retene requires metabolic competence.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- [Chemical pollution, exposome and health in the Canary Islands population: An assessment of the situation.]Revista espanola de salud publica · 2023Review
- Long-term ambient hydrocarbon exposure and incidence of urinary bladder cancer.Scientific reports · 2022Article
- Article
- Associations and dose-response relationships between different kinds of urine polycyclic aromatic hydrocarbons metabolites and adult lung functions.Environmental science and pollution research international · 2022Article
- Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution.Molecules (Basel, Switzerland) · 2021Article
- Article
- Pollution Sources and Carcinogenic Risk of PAHs in PMInternational journal of environmental research and public health · 2020Article
- Article
- Exposure to polycyclic aromatic hydrocarbons and risk of disability among an elderly population.Environmental science and pollution research international · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to bladder cancer.
objectiveTo evaluate the role of PAHs in bladder cancer, PAHs serum levels were measured in patients and controls from a case-control study.
methodsA total of 140 bladder cancer patients and 206 healthy controls were included in the study. Sixteen PAHs were analyzed from the serum of subjects by gas chromatography-mass spectrometry.
resultsSerum PAHs did not appear to be related to bladder cancer risk, although the profile of contamination by PAHs was different between patients and controls: pyrene (Pyr) was solely detected in controls and chrysene (Chry) was exclusively detected in the cases. Phenanthrene (Phe) serum levels were inversely associated with bladder cancer (OR = 0·79, 95%CI = 0·64-0·99, P = 0·030), although this effect disappeared when the allelic distribution of glutathione-S-transferase polymorphisms of the population was introduced into the model (multinomial logistic regression test, P = 0·933). Smoking (OR = 3·62, 95%CI = 1·93-6·79, P<0·0001) and coffee consumption (OR = 1·73, 95%CI = 1·04-2·86, P = 0·033) were relevant risk factors for bladder cancer.
conclusionsSpecific PAH mixtures may play a relevant role in bladder cancer, although such effect seems to be highly modulated by polymorphisms in genes encoding xenobiotic-metabolizing enzymes.
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