ArticleNature structural & molecular biology2014
Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog.
Article in Nature structural & molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Phage-encoded NARP3 system rebuilds NADScience advances · 2026Article
- Regulation of NADMetabolism: clinical and experimental · 2022Review
- Toward a Molecular Basis of Cellular Nucleoside Transport in Humans.Chemical reviews · 2021Review
- The ins and outs of SWEETs in plants: Current understanding of the basics and their prospects in crop improvement.Journal of biosciences · 2021Review
- Sugar and Hormone Dynamics and the Expression Profiles of SUT/SUC and SWEET Sweet Sugar Transporters during Flower Development inPlants (Basel, Switzerland) · 2020Article
- Sequence Features of Mitochondrial Transporter Protein Families.Biomolecules · 2020Review
- Protein Disulfide Exchange by the Intramembrane Enzymes DsbB, DsbD, and CcdA.Journal of molecular biology · 2020Review
- Pseudo-Symmetric Assembly of Protodomains as a Common Denominator in the Evolution of Polytopic Helical Membrane Proteins.Journal of molecular evolution · 2020Article
- Structural and Functional Characterization of NadR fromMolecules (Basel, Switzerland) · 2020Article
- Genome-wide identification and expression analysis of the StSWEET family genes in potato (Solanum tuberosum L.).Genes & genomics · 2020Article
- Expansion of the Transporter-Opsin-G protein-coupled receptor superfamily with five new protein families.PloS one · 2020Article
- Structure, evolution and diverse physiological roles of SWEET sugar transporters in plants.Plant molecular biology · 2019Review
- Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM.Nature communications · 2018Article
- Solution structure and elevator mechanism of the membrane electron transporter CcdA.Nature structural & molecular biology · 2018Article
- PnuT uses a facilitated diffusion mechanism for thiamine uptake.The Journal of general physiology · 2018Article
- A topologically diverse family of fluoride channels.Current opinion in structural biology · 2017Review
- Niacin-mediated Gene Expression and Role of NiaR as a Transcriptional Repressor ofFrontiers in cellular and infection microbiology · 2017Article
- Functional mining of transporters using synthetic selections.Nature chemical biology · 2016Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PnuC transporters catalyze cellular uptake of the NAD+ precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3+1+3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.
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